Abstract
Purpose: The purpose of this case report is to describe spasticity and encephalopathy that developed in a multiple sclerosis patient following carbapenem administration. Summary: A 55-year-old female with multiple sclerosis developed spasticity and encephalopathy within 24 hours of meropenem and ertapenem administration. This was the second time that she had developed encephalopathy following carbapenem administration. The patient gradually recovered over four days following discontinuation of carbapenem therapy. Conclusion: Carbapenem neurotoxicity, a well-documented adverse effect, has been linked to several risk factors, including central nervous system lesions. Despite this, there is little evidence describing the risk of neurotoxicity in patients with multiple sclerosis. It is important to understand the potential adverse effects of carbapenems in specific patient populations to help guide appropriate treatment of infections.
Original language | English (US) |
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Pages (from-to) | 699-704 |
Number of pages | 6 |
Journal | Journal of Pharmacy Practice |
Volume | 36 |
Issue number | 3 |
DOIs | |
State | Published - Jun 2023 |
Keywords
- carbapenem
- case report
- encephalopathy
- multiple sclerosis
- spasticity
ASJC Scopus subject areas
- Pharmacology (medical)