Primary pulmonary hypertension is not associated with scleroderma-like changes in nailfold capillaries

E. L. Greidinger, S. P. Gaine, R. A. Wise, C. Boling, T. Housten-Harris, F. M. Wigley

Research output: Contribution to journalArticlepeer-review

20 Scopus citations


Study objectives: To determine whether primary pulmonary hypertension (PPH) is associated with scleroderma-like changes in nailfold capillaries. Design: Blinded, prospective, case-control study. Setting: University medical centers in Baltimore, MD. Patients: Thirty-seven patients with PPH, 15 patients with scleroderma, and 13 healthy control subjects. Measurements: Subjects underwent nailfold capillary videomicroscopy of the fourth digits of both hands. Capillary images were evaluated by two blinded, trained graders according to standardized criteria for the presence of scleroderma nailfold changes. Results: The prevalence of scleroderma-associated nailfold changes in patients with PPH (1 of 37 patients) was dramatically lower than that in patients with scleroderma (9 of 15 patients; p < 0.0001). The distribution of nailfold grades for the PPH patients was indistinguishable from that of the healthy control subjects. Conclusion: PPH is not associated with scleroderma-like vasculopathy of nailfold capillaries.

Original languageEnglish (US)
Pages (from-to)796-800
Number of pages5
Issue number3
StatePublished - Sep 2001


  • Nailfold capillaroscopy
  • Primary pulmonary hypertension
  • Scleroderma

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Critical Care and Intensive Care Medicine
  • Cardiology and Cardiovascular Medicine


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