TY - JOUR
T1 - Primary Lymphopenic Immunologic Deficiency
T2 - Disseminated Mycobacterium kansasii Infection
AU - McCracken, G. H.
AU - Reynolds, R. C.
N1 - Copyright:
Copyright 2015 Elsevier B.V., All rights reserved.
PY - 1970/8
Y1 - 1970/8
N2 - A 7½-month-old boy with primary lymphopenic immunologic deficiency, disseminated Mycobacterium kansasii infection, and Pneumocystis carinii pneumonia had a profound defect in lymphocytemediated immunity associated with a selective immunoglobulin deficiency. There was evidence of IgM and IgG antibody activity. Leukocyte phagocytic function was normal, but opsonin and total hemolytic complement activity was found to be markedly low. Disseminated atypical mycobacterial infection has been previously described in 27 cases. Altered host resistance has been postulated in the pathogenesis, but the present case is the first reported with documented immunologic deficiency. The immunopathology of this patient's mycobacterial infection is similar to that described in infants with fatal disseminated BCG infection.
AB - A 7½-month-old boy with primary lymphopenic immunologic deficiency, disseminated Mycobacterium kansasii infection, and Pneumocystis carinii pneumonia had a profound defect in lymphocytemediated immunity associated with a selective immunoglobulin deficiency. There was evidence of IgM and IgG antibody activity. Leukocyte phagocytic function was normal, but opsonin and total hemolytic complement activity was found to be markedly low. Disseminated atypical mycobacterial infection has been previously described in 27 cases. Altered host resistance has been postulated in the pathogenesis, but the present case is the first reported with documented immunologic deficiency. The immunopathology of this patient's mycobacterial infection is similar to that described in infants with fatal disseminated BCG infection.
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U2 - 10.1001/archpedi.1970.02100070087011
DO - 10.1001/archpedi.1970.02100070087011
M3 - Article
C2 - 5311533
AN - SCOPUS:0014837423
SN - 0096-8994
VL - 120
SP - 143
EP - 147
JO - American Journal of Diseases of Children
JF - American Journal of Diseases of Children
IS - 2
ER -