Prevention of preeclampsia and eclampsia

Anne Cathrine Staff, Baha M. Sibai, F. Gary Cunningham

Research output: Chapter in Book/Report/Conference proceedingChapter

6 Scopus citations


There have been many randomized trials to determine whether preeclampsia/eclampsia, a major cause of maternal and perinatal mortality and morbidity, can be prevented. Most were designed to evaluate whether low-dose aspirin regimens prevent preeclampsia. The results subjected to meta-analysis revealed a 10% reduction in the incidence of preeclampsia in women assigned low-dose aspirin, but very little improvement in morbid outcomes. There were least 10 randomized trials in which prevention by calcium supplementation (1.5 to 2 g/d) was evaluated, their results subjected to two systematic reviews whose conclusions conflict. Other trials evaluated use of fish oil or vitamins C and E supplementation for the prevention of preeclampsia in low- and high-risk pregnant women. Through 2013 these latter studies have all been negative. There have also been randomized trials evaluating use of magnesium sulfate to prevent eclampsia, demonstrating a reduction in the rate of seizures by one half.

Original languageEnglish (US)
Title of host publicationChesley's Hypertensive Disorders in Pregnancy, Fourth Edition
PublisherElsevier Science
Number of pages15
ISBN (Electronic)9780124078666
StatePublished - Jan 1 2014


  • Antioxidants
  • Calcium supplementation
  • Eclampsia
  • Low-dose aspirin
  • Magnesium sulfate
  • Preeclampsia
  • Prevention

ASJC Scopus subject areas

  • General Medicine


Dive into the research topics of 'Prevention of preeclampsia and eclampsia'. Together they form a unique fingerprint.

Cite this