Presurgical plasma exchange is ineffective in correcting amyloid associated factor X deficiency

Brad Barker; Fevzi Altuntas; Geeta Paranjape; Ravindra Sarode

doi:10.1002/jca.20031

Presurgical plasma exchange is ineffective in correcting amyloid associated factor X deficiency

Brad Barker, Fevzi Altuntas, Geeta Paranjape, Ravindra Sarode

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

In patients with rare factor deficiencies, for which no factor concentrates are available, plasma exchange (PE) is an option for raising the desired factor level to approximately 80% for surgery. We report a case of acquired factor X (FX) deficiency due to amyloidosis that required urgent surgical repair of an AV fistula aneurysm. This patient had a FX level of 3% at presentation; after 1.5 volume PE with fresh frozen plasma (FFP), his post-exchange FX was only 5%, indicating rapid adsorption of FX to amyloid fibrils. He was managed successfully with FEIBA during surgery.

Original language	English (US)
Pages (from-to)	208-210
Number of pages	3
Journal	Journal of Clinical Apheresis
Volume	19
Issue number	4
DOIs	https://doi.org/10.1002/jca.20031
State	Published - Dec 1 2004

Keywords

Amyloidosis
Factor X deficiency
Plasma exchange

ASJC Scopus subject areas

Hematology

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10.1002/jca.20031

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title = "Presurgical plasma exchange is ineffective in correcting amyloid associated factor X deficiency",

abstract = "In patients with rare factor deficiencies, for which no factor concentrates are available, plasma exchange (PE) is an option for raising the desired factor level to approximately 80% for surgery. We report a case of acquired factor X (FX) deficiency due to amyloidosis that required urgent surgical repair of an AV fistula aneurysm. This patient had a FX level of 3% at presentation; after 1.5 volume PE with fresh frozen plasma (FFP), his post-exchange FX was only 5%, indicating rapid adsorption of FX to amyloid fibrils. He was managed successfully with FEIBA during surgery.",

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AU - Sarode, Ravindra

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N2 - In patients with rare factor deficiencies, for which no factor concentrates are available, plasma exchange (PE) is an option for raising the desired factor level to approximately 80% for surgery. We report a case of acquired factor X (FX) deficiency due to amyloidosis that required urgent surgical repair of an AV fistula aneurysm. This patient had a FX level of 3% at presentation; after 1.5 volume PE with fresh frozen plasma (FFP), his post-exchange FX was only 5%, indicating rapid adsorption of FX to amyloid fibrils. He was managed successfully with FEIBA during surgery.

AB - In patients with rare factor deficiencies, for which no factor concentrates are available, plasma exchange (PE) is an option for raising the desired factor level to approximately 80% for surgery. We report a case of acquired factor X (FX) deficiency due to amyloidosis that required urgent surgical repair of an AV fistula aneurysm. This patient had a FX level of 3% at presentation; after 1.5 volume PE with fresh frozen plasma (FFP), his post-exchange FX was only 5%, indicating rapid adsorption of FX to amyloid fibrils. He was managed successfully with FEIBA during surgery.

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KW - Plasma exchange

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Presurgical plasma exchange is ineffective in correcting amyloid associated factor X deficiency

Abstract

Keywords

ASJC Scopus subject areas

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