Presence of simian virus 40 DNA sequences in human lymphomas

Narayan Shivapurkar; Kenichi Harada; Jyotsna Reddy; Richard H. Scheuermann; Yin Xu; Robert W. McKenna; Sara Milchgrub; Steven H. Kroft; Ziding Feng; Adi F. Gazdar

doi:10.1016/S0140-6736(02)07921-7

Presence of simian virus 40 DNA sequences in human lymphomas

Narayan Shivapurkar, Kenichi Harada, Jyotsna Reddy, Richard H. Scheuermann, Yin Xu, Robert W. McKenna, Sara Milchgrub, Steven H. Kroft, Ziding Feng, Adi F. Gazdar

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140 Scopus citations

Abstract

Simian virus 40 (SV40) - a potent oncogenic virus - has been associated previously with some types of human tumours, but not with lymphomas. We examined human tumours for the presence of specific SV40 DNA sequences by PCR and Southern blotting. Viral sequences were present in 29 (43%) of 68 non-Hodgkin lymphomas, and in three (9%) of 31 of Hodgkin's lymphomas. Viral sequences were detected at low frequencies (about 5%) in 235 epithelial tumours of adult and paediatric origin, and were absent in 40 control tissues. Our data suggest that SV40 might be a cofactor in the pathogenesis of non-Hodgkin lymphomas.

Original language	English (US)
Pages (from-to)	851-852
Number of pages	2
Journal	Lancet
Volume	359
Issue number	9309
DOIs	https://doi.org/10.1016/S0140-6736(02)07921-7
State	Published - Mar 9 2002

ASJC Scopus subject areas

General Medicine

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title = "Presence of simian virus 40 DNA sequences in human lymphomas",

abstract = "Simian virus 40 (SV40) - a potent oncogenic virus - has been associated previously with some types of human tumours, but not with lymphomas. We examined human tumours for the presence of specific SV40 DNA sequences by PCR and Southern blotting. Viral sequences were present in 29 (43%) of 68 non-Hodgkin lymphomas, and in three (9%) of 31 of Hodgkin's lymphomas. Viral sequences were detected at low frequencies (about 5%) in 235 epithelial tumours of adult and paediatric origin, and were absent in 40 control tissues. Our data suggest that SV40 might be a cofactor in the pathogenesis of non-Hodgkin lymphomas.",

author = "Narayan Shivapurkar and Kenichi Harada and Jyotsna Reddy and Scheuermann, {Richard H.} and Yin Xu and McKenna, {Robert W.} and Sara Milchgrub and Kroft, {Steven H.} and Ziding Feng and Gazdar, {Adi F.}",

note = "Funding Information: We thank Gail Tomlinson, Shinichi Toyooka, Domenico Mastrangelo, Anirban Maitra, Asha Padar, and Riichioh Maruyama for contributing some of the non-lymphoma samples. Funding for this study was provided by a grant from the Early Detection Research Network, National Cancer Institute, Bethesda, Maryland, USA.",

year = "2002",

month = mar,

day = "9",

doi = "10.1016/S0140-6736(02)07921-7",

language = "English (US)",

volume = "359",

pages = "851--852",

journal = "Lancet",

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publisher = "Elsevier Limited",

number = "9309",

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TY - JOUR

T1 - Presence of simian virus 40 DNA sequences in human lymphomas

AU - Shivapurkar, Narayan

AU - Harada, Kenichi

AU - Reddy, Jyotsna

AU - Scheuermann, Richard H.

AU - Xu, Yin

AU - McKenna, Robert W.

AU - Milchgrub, Sara

AU - Kroft, Steven H.

AU - Feng, Ziding

AU - Gazdar, Adi F.

N1 - Funding Information: We thank Gail Tomlinson, Shinichi Toyooka, Domenico Mastrangelo, Anirban Maitra, Asha Padar, and Riichioh Maruyama for contributing some of the non-lymphoma samples. Funding for this study was provided by a grant from the Early Detection Research Network, National Cancer Institute, Bethesda, Maryland, USA.

PY - 2002/3/9

Y1 - 2002/3/9

N2 - Simian virus 40 (SV40) - a potent oncogenic virus - has been associated previously with some types of human tumours, but not with lymphomas. We examined human tumours for the presence of specific SV40 DNA sequences by PCR and Southern blotting. Viral sequences were present in 29 (43%) of 68 non-Hodgkin lymphomas, and in three (9%) of 31 of Hodgkin's lymphomas. Viral sequences were detected at low frequencies (about 5%) in 235 epithelial tumours of adult and paediatric origin, and were absent in 40 control tissues. Our data suggest that SV40 might be a cofactor in the pathogenesis of non-Hodgkin lymphomas.

AB - Simian virus 40 (SV40) - a potent oncogenic virus - has been associated previously with some types of human tumours, but not with lymphomas. We examined human tumours for the presence of specific SV40 DNA sequences by PCR and Southern blotting. Viral sequences were present in 29 (43%) of 68 non-Hodgkin lymphomas, and in three (9%) of 31 of Hodgkin's lymphomas. Viral sequences were detected at low frequencies (about 5%) in 235 epithelial tumours of adult and paediatric origin, and were absent in 40 control tissues. Our data suggest that SV40 might be a cofactor in the pathogenesis of non-Hodgkin lymphomas.

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U2 - 10.1016/S0140-6736(02)07921-7

DO - 10.1016/S0140-6736(02)07921-7

M3 - Article

C2 - 11897287

AN - SCOPUS:0037045832

SN - 0140-6736

VL - 359

SP - 851

EP - 852

JO - Lancet

JF - Lancet

IS - 9309

ER -

Presence of simian virus 40 DNA sequences in human lymphomas

Abstract

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