TY - JOUR
T1 - Predictive value of plasma hepatocyte growth factor/scatter factor levels in patients with clinically localized prostate cancer
AU - Gupta, Amit
AU - Karakiewicz, Pierre I.
AU - Roehrborn, Claus
AU - Lotan, Yair
AU - Zlotta, Alexandre R.
AU - Shariat, Shahrokh F.
PY - 2008/11/15
Y1 - 2008/11/15
N2 - Purpose: Hepatocyte growth factor/scatter factor (HGF/SF) is a multifunctional cytokine that is involved in cancer growth, motility, invasion, and angiogenesis. We assessed whether preoperative plasma levels of HGF can enhance the accuracy of standard models for predicting pathologic features and clinical outcomes. Experimental Design: The study comprised 421 consecutive patients treated with radical prostatectomy and bilateral lymphadenectomy for clinically localized prostatic adenocarcinoma. HGF/ SF was measured using a commercially available immunoassay. Multivariate logistic regression was used to assess the relationship between plasma HGF/SF and pathologic features. Multivariate Coxr egression was used to predict disease recurrence. One thousand bootstrap replicates were created for internal validation and predictive accuracies were estimated for eachmodel. Results: Plasma HGF/SF levels were significantly elevated in patients with lymph node and/or seminal vesicle invasion (P < 0.0001 and P = 0.007, respectively). Preoperative plasma HGF/SF level was an independent predictor of lymph node invasion [odds ratio (OR) for every100 pg/mL increase in HGF/SF,1.82; 95% confidence interval (95% CI),1.33-2.49] and seminal vesicle invasion (OR,1.18; 95% CI,1.06-1.3). Addition of HGF/SF increased the accuracy of a base model that included standard preoperative variables for prediction of lymph node invasion by 6.7% (predictive accuracy, 98.4%). HGF/SF also independently predicted disease recurrence after surgery (hazard ratio,1.07; 95% CI,1.0-1.15). Conclusions: Preoperative plasma level of HGF/SF is an independent predictor of prostate cancer metastasis to lymph nodes and disease recurrence after surgery. Use of HGF may help in therapeutic decision-making and enrollment into clinical trials.
AB - Purpose: Hepatocyte growth factor/scatter factor (HGF/SF) is a multifunctional cytokine that is involved in cancer growth, motility, invasion, and angiogenesis. We assessed whether preoperative plasma levels of HGF can enhance the accuracy of standard models for predicting pathologic features and clinical outcomes. Experimental Design: The study comprised 421 consecutive patients treated with radical prostatectomy and bilateral lymphadenectomy for clinically localized prostatic adenocarcinoma. HGF/ SF was measured using a commercially available immunoassay. Multivariate logistic regression was used to assess the relationship between plasma HGF/SF and pathologic features. Multivariate Coxr egression was used to predict disease recurrence. One thousand bootstrap replicates were created for internal validation and predictive accuracies were estimated for eachmodel. Results: Plasma HGF/SF levels were significantly elevated in patients with lymph node and/or seminal vesicle invasion (P < 0.0001 and P = 0.007, respectively). Preoperative plasma HGF/SF level was an independent predictor of lymph node invasion [odds ratio (OR) for every100 pg/mL increase in HGF/SF,1.82; 95% confidence interval (95% CI),1.33-2.49] and seminal vesicle invasion (OR,1.18; 95% CI,1.06-1.3). Addition of HGF/SF increased the accuracy of a base model that included standard preoperative variables for prediction of lymph node invasion by 6.7% (predictive accuracy, 98.4%). HGF/SF also independently predicted disease recurrence after surgery (hazard ratio,1.07; 95% CI,1.0-1.15). Conclusions: Preoperative plasma level of HGF/SF is an independent predictor of prostate cancer metastasis to lymph nodes and disease recurrence after surgery. Use of HGF may help in therapeutic decision-making and enrollment into clinical trials.
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U2 - 10.1158/1078-0432.CCR-07-5110
DO - 10.1158/1078-0432.CCR-07-5110
M3 - Article
C2 - 19010854
AN - SCOPUS:58149347700
SN - 1078-0432
VL - 14
SP - 7385
EP - 7390
JO - Clinical Cancer Research
JF - Clinical Cancer Research
IS - 22
ER -