Predictive markers for response to chemotherapy, organ preservation, and survival in patients with advanced laryngeal carcinoma

C. R. Bradford; G. T. Wolf; T. E. Carey; S. Zhu; T. F. Beals; J. M. Truelson; K. D. McClatchey; S. G. Fisher

doi:10.1016/S0194-5998(99)70052-5

Predictive markers for response to chemotherapy, organ preservation, and survival in patients with advanced laryngeal carcinoma

C. R. Bradford, G. T. Wolf, T. E. Carey, S. Zhu, T. F. Beals, J. M. Truelson, K. D. McClatchey, S. G. Fisher

Research output: Contribution to journal › Article › peer-review

61 Scopus citations

Abstract

OBJECTIVE: A systematic retrospective study of the largest randomized trial of induction chemotherapy and radiation for advanced laryngeal cancer was undertaken to determine whether specific tumor or biologic factors were predictive of chemotherapy response, organ preservation, or survival. METHODS: The variables analyzed included clinical and histologic factors, immunohistochemical expression of proliferating cell nuclear antigen and p53, and adjusted DNA index measurements. Variables were evaluated for correlation with outcomes of tumor response, organ preservation, and survival. RESULTS: Multivariate analysis revealed that the best predictor of complete response to induction chemotherapy was low T class. The full multivariate model for predicting larynx preservation in patients treated with induction chemotherapy plus radiation shows that T class, p53 overexpression, and elevated proliferating cell nuclear antigen index were independent predictors of successful organ preservation. CONCLUSIONS: These predictive markers should be included in future clinical trials of advanced laryngeal cancer to determine their usefulness prospectively.

Original language	English (US)
Pages (from-to)	534-538
Number of pages	5
Journal	Otolaryngology - Head and Neck Surgery
Volume	121
Issue number	5
DOIs	https://doi.org/10.1016/S0194-5998(99)70052-5
State	Published - 1999

ASJC Scopus subject areas

Surgery
Otorhinolaryngology

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title = "Predictive markers for response to chemotherapy, organ preservation, and survival in patients with advanced laryngeal carcinoma",

abstract = "OBJECTIVE: A systematic retrospective study of the largest randomized trial of induction chemotherapy and radiation for advanced laryngeal cancer was undertaken to determine whether specific tumor or biologic factors were predictive of chemotherapy response, organ preservation, or survival. METHODS: The variables analyzed included clinical and histologic factors, immunohistochemical expression of proliferating cell nuclear antigen and p53, and adjusted DNA index measurements. Variables were evaluated for correlation with outcomes of tumor response, organ preservation, and survival. RESULTS: Multivariate analysis revealed that the best predictor of complete response to induction chemotherapy was low T class. The full multivariate model for predicting larynx preservation in patients treated with induction chemotherapy plus radiation shows that T class, p53 overexpression, and elevated proliferating cell nuclear antigen index were independent predictors of successful organ preservation. CONCLUSIONS: These predictive markers should be included in future clinical trials of advanced laryngeal cancer to determine their usefulness prospectively.",

author = "Bradford, {C. R.} and Wolf, {G. T.} and Carey, {T. E.} and S. Zhu and Beals, {T. F.} and Truelson, {J. M.} and McClatchey, {K. D.} and Fisher, {S. G.}",

note = "Funding Information: Supported by the 1997 Percy Memorial Research Award and the American Society of Clinical Oncology Career Development Award (C.R.B.) and by the Cooperative Studies Program, Hines Department of Veterans Affairs Medical Center, Chicago. ",

year = "1999",

doi = "10.1016/S0194-5998(99)70052-5",

language = "English (US)",

volume = "121",

pages = "534--538",

journal = "Otolaryngology - Head and Neck Surgery",

issn = "0194-5998",

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TY - JOUR

T1 - Predictive markers for response to chemotherapy, organ preservation, and survival in patients with advanced laryngeal carcinoma

AU - Bradford, C. R.

AU - Wolf, G. T.

AU - Carey, T. E.

AU - Zhu, S.

AU - Beals, T. F.

AU - Truelson, J. M.

AU - McClatchey, K. D.

AU - Fisher, S. G.

N1 - Funding Information: Supported by the 1997 Percy Memorial Research Award and the American Society of Clinical Oncology Career Development Award (C.R.B.) and by the Cooperative Studies Program, Hines Department of Veterans Affairs Medical Center, Chicago.

PY - 1999

Y1 - 1999

N2 - OBJECTIVE: A systematic retrospective study of the largest randomized trial of induction chemotherapy and radiation for advanced laryngeal cancer was undertaken to determine whether specific tumor or biologic factors were predictive of chemotherapy response, organ preservation, or survival. METHODS: The variables analyzed included clinical and histologic factors, immunohistochemical expression of proliferating cell nuclear antigen and p53, and adjusted DNA index measurements. Variables were evaluated for correlation with outcomes of tumor response, organ preservation, and survival. RESULTS: Multivariate analysis revealed that the best predictor of complete response to induction chemotherapy was low T class. The full multivariate model for predicting larynx preservation in patients treated with induction chemotherapy plus radiation shows that T class, p53 overexpression, and elevated proliferating cell nuclear antigen index were independent predictors of successful organ preservation. CONCLUSIONS: These predictive markers should be included in future clinical trials of advanced laryngeal cancer to determine their usefulness prospectively.

AB - OBJECTIVE: A systematic retrospective study of the largest randomized trial of induction chemotherapy and radiation for advanced laryngeal cancer was undertaken to determine whether specific tumor or biologic factors were predictive of chemotherapy response, organ preservation, or survival. METHODS: The variables analyzed included clinical and histologic factors, immunohistochemical expression of proliferating cell nuclear antigen and p53, and adjusted DNA index measurements. Variables were evaluated for correlation with outcomes of tumor response, organ preservation, and survival. RESULTS: Multivariate analysis revealed that the best predictor of complete response to induction chemotherapy was low T class. The full multivariate model for predicting larynx preservation in patients treated with induction chemotherapy plus radiation shows that T class, p53 overexpression, and elevated proliferating cell nuclear antigen index were independent predictors of successful organ preservation. CONCLUSIONS: These predictive markers should be included in future clinical trials of advanced laryngeal cancer to determine their usefulness prospectively.

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JO - Otolaryngology - Head and Neck Surgery

JF - Otolaryngology - Head and Neck Surgery

IS - 5

ER -

Predictive markers for response to chemotherapy, organ preservation, and survival in patients with advanced laryngeal carcinoma

Abstract

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