TY - JOUR
T1 - Preclinical models of middle cerebral artery occlusion
T2 - new imaging approaches to a classic technique
AU - Sokolowski, Jennifer D.
AU - Soldozy, Sauson
AU - Sharifi, Khadijeh A.
AU - Norat, Pedro
AU - Kearns, Kathryn N.
AU - Liu, Lei
AU - Williams, Ashley M.
AU - Yağmurlu, Kaan
AU - Mastorakos, Panagiotis
AU - Miller, G. Wilson
AU - Kalani, M. Yashar S.
AU - Park, Min S.
AU - Kellogg, Ryan T.
AU - Tvrdik, Petr
N1 - Publisher Copyright:
Copyright © 2023 Sokolowski, Soldozy, Sharifi, Norat, Kearns, Liu, Williams, Yağmurlu, Mastorakos, Miller, Kalani, Park, Kellogg and Tvrdik.
PY - 2023
Y1 - 2023
N2 - Stroke remains a major burden on patients, families, and healthcare professionals, despite major advances in prevention, acute treatment, and rehabilitation. Preclinical basic research can help to better define mechanisms contributing to stroke pathology, and identify therapeutic interventions that can decrease ischemic injury and improve outcomes. Animal models play an essential role in this process, and mouse models are particularly well-suited due to their genetic accessibility and relatively low cost. Here, we review the focal cerebral ischemia models with an emphasis on the middle cerebral artery occlusion technique, a “gold standard” in surgical ischemic stroke models. Also, we highlight several histologic, genetic, and in vivo imaging approaches, including mouse stroke MRI techniques, that have the potential to enhance the rigor of preclinical stroke evaluation. Together, these efforts will pave the way for clinical interventions that can mitigate the negative impact of this devastating disease.
AB - Stroke remains a major burden on patients, families, and healthcare professionals, despite major advances in prevention, acute treatment, and rehabilitation. Preclinical basic research can help to better define mechanisms contributing to stroke pathology, and identify therapeutic interventions that can decrease ischemic injury and improve outcomes. Animal models play an essential role in this process, and mouse models are particularly well-suited due to their genetic accessibility and relatively low cost. Here, we review the focal cerebral ischemia models with an emphasis on the middle cerebral artery occlusion technique, a “gold standard” in surgical ischemic stroke models. Also, we highlight several histologic, genetic, and in vivo imaging approaches, including mouse stroke MRI techniques, that have the potential to enhance the rigor of preclinical stroke evaluation. Together, these efforts will pave the way for clinical interventions that can mitigate the negative impact of this devastating disease.
KW - core
KW - focal ischemia
KW - ischemic stroke
KW - middle cerebral artery occlusion
KW - penumbra
KW - rodent model
UR - http://www.scopus.com/inward/record.url?scp=85164501856&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85164501856&partnerID=8YFLogxK
U2 - 10.3389/fneur.2023.1170675
DO - 10.3389/fneur.2023.1170675
M3 - Review article
C2 - 37409019
AN - SCOPUS:85164501856
SN - 1664-2295
VL - 14
JO - Frontiers in Neurology
JF - Frontiers in Neurology
M1 - 1170675
ER -