Practical, asymmetric synthesis of 16-hydroxyeicosa-5(Z),8(Z),11(Z),14(Z)-tetraenoic acid (16-HETE), an endogenous inhibitor of neutrophil activity

Y. Krishna Reddy; L. Manmohan Reddy; Jorge H. Capdevila; J R Falck

doi:10.1016/j.bmcl.2003.08.005

Practical, asymmetric synthesis of 16-hydroxyeicosa-5(Z),8(Z),11(Z),14(Z)-tetraenoic acid (16-HETE), an endogenous inhibitor of neutrophil activity

Y. Krishna Reddy, L. Manmohan Reddy, Jorge H. Capdevila, J R Falck

Biochemistry

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

An asymmetric synthesis of 16-HETE, an endogenous inhibitor of neutrophil activity, was achieved in six steps from R-(-)-glycidyl benzyl ether in 28% overall yield.

Original language	English (US)
Pages (from-to)	3719-3720
Number of pages	2
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	13
Issue number	21
DOIs	https://doi.org/10.1016/j.bmcl.2003.08.005
State	Published - Nov 3 2003

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

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10.1016/j.bmcl.2003.08.005

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Practical, asymmetric synthesis of 16-hydroxyeicosa-5(Z),8(Z),11(Z),14(Z)-tetraenoic acid (16-HETE), an endogenous inhibitor of neutrophil activity. / Reddy, Y. Krishna; Reddy, L. Manmohan; Capdevila, Jorge H. et al.
In: Bioorganic and Medicinal Chemistry Letters, Vol. 13, No. 21, 03.11.2003, p. 3719-3720.

Research output: Contribution to journal › Article › peer-review

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title = "Practical, asymmetric synthesis of 16-hydroxyeicosa-5(Z),8(Z),11(Z),14(Z)-tetraenoic acid (16-HETE), an endogenous inhibitor of neutrophil activity",

abstract = "An asymmetric synthesis of 16-HETE, an endogenous inhibitor of neutrophil activity, was achieved in six steps from R-(-)-glycidyl benzyl ether in 28% overall yield.",

author = "Reddy, {Y. Krishna} and Reddy, {L. Manmohan} and Capdevila, {Jorge H.} and Falck, {J R}",

note = "Funding Information: Supported financially by the USPHS NIH (DK38226, GM37922) and the Robert A. Welch Foundation. The authors are grateful to Dr. Naoya Ono for his critical review of the manuscript.",

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AU - Reddy, L. Manmohan

AU - Capdevila, Jorge H.

AU - Falck, J R

N1 - Funding Information: Supported financially by the USPHS NIH (DK38226, GM37922) and the Robert A. Welch Foundation. The authors are grateful to Dr. Naoya Ono for his critical review of the manuscript.

PY - 2003/11/3

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ER -

Practical, asymmetric synthesis of 16-hydroxyeicosa-5(Z),8(Z),11(Z),14(Z)-tetraenoic acid (16-HETE), an endogenous inhibitor of neutrophil activity

Abstract

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