Postsynaptic supersensitivity in schizophrenia

G. N. Pandey, D. L. Garver, C. Tamminga, S. Ericksen, S. I. Ali, J. M. Davis

Research output: Contribution to journalArticlepeer-review

72 Scopus citations


In the context of the dopamine hypothesis of schizophrenia, the authors examined postsynaptic dopamine (DA) receptor sensitivity in schizophrenic patients by means of a neuroendocrine strategy using the DA receptor agonist apomorphine and growth hormone (GH) release as the measurable postsynaptic event. The activity of platelet adenylate cyclase, an enzyme intimately associated with catecholamine receptor activity, was also studied following stimulation by prostaglandin E1 (PGE1). Patients diagnosed as having acute schizophrenia had significantly higher GH responses and adenylate cyclase activity than normal control subjects and patients diagnosed as having chronic schizophrenia. Chronic schizophrenic patients with and without tardive dyskinesia showed GH responses slightly lower than but not significantly different from those of control groups.

Original languageEnglish (US)
Pages (from-to)518-522
Number of pages5
JournalUnknown Journal
Issue number5
StatePublished - Jan 1 1977

ASJC Scopus subject areas

  • Psychiatry and Mental health


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