Possible relationship of gastroesophagopharyngeal acid reflux with pathogenesis of chronic sinusitis

Seckin O. Ulualp, Robert J. Toohill, Raymond Hoffmann, Reza Shaker

Research output: Contribution to journalArticlepeer-review

120 Scopus citations


Gastroesophagopharyngeal reflux (GEPR) has been suggested as a cause of pédiatrie sinusitis. However, its contribution to the pathogenesis of chronic sinusitis in adults has not been systematically investigated. We evaluated the prevalence of GEPR in II CT confirmed chronic sinusitis patients (51 ± 4 years) who had not responded to conventional therapy, and II normal healthy controls (44 ±7 years). A 3-site ambulatory esophagopharyngeal pH monitoring technique (probe location: 2 cm proximal, 3-4 cm distal to UES and 5 cm proximal to LES high pressure zones) was used. A pharyngeal pH drop was accepted as a true reflux event only if it was coincident with or preceded by esophageal pH declines of a similar or larger magnitude. Studies were performed while subjects were on a uniform 2500 calorie diet (provided). Results: Ambulatory pH monitoring documented GEPR in seven of 11 patients (1-12 episodes) and two of 11 normal volunteers (1,2 episodes) (p < 0.05). A total of 34 nonbelch related pharyngeal acid reflux events were identified in patients, but none was associated with coughing. In both groups, all pharyngeal acid events occurred in the upright position. Compared to normal controls prevalence of pharyngeal reflux of gastric acid is significantly higher in patients with chronic sinusitis unresponsive to conventional therapy and suggests a different esophagopharyngeal distribution pattern of gastric refluxate in this patient group; these findings suggest that GEPR may contribute to the pathogenesis of chronic sinusitis in some adult patients.

Original languageEnglish (US)
Pages (from-to)197-202
Number of pages6
JournalAmerican Journal of Rhinology
Issue number3
StatePublished - 1999

ASJC Scopus subject areas

  • Otorhinolaryngology


Dive into the research topics of 'Possible relationship of gastroesophagopharyngeal acid reflux with pathogenesis of chronic sinusitis'. Together they form a unique fingerprint.

Cite this