TY - JOUR
T1 - Possible association but no linkage of the HSD11B2 gene encoding the kidney isozyme of 11β-hydroxysteroid dehydrogenase to hypertension in Black people
AU - White, Perrin C.
AU - Agarwal, Anil K.
AU - Li, Airong
AU - Howard Pratt, Heli Nikkila J
AU - Caulfield, Mark
AU - Clark, Adrian
AU - McTernan, Claire
AU - Stewart, Paul M.
PY - 2001
Y1 - 2001
N2 - OBJECTIVE: The HSD11B2 (HSD11K) gene encoding the kidney isozyme of 11β-hydroxysteroid dehydrogenase is mutated in the syndrome of apparent mineralocorticoid excess, an autosomal recessive form of salt-sensitive hypertension. This gene is thus a logical candidate locus for risk of essential hypertension. DESIGN AND METHODS: Because hypertension in Black people tends to be of the low-renin, salt sensitive type, we genotyped independent sets of hypertensives of Afro-American (59 kindreds) and Afro-Caribbean (66 kindreds) origin using a highly polymorphic (heterozygosity index 0.84) CA repeat polymorphism in the first intron of HSD11B2. Linkage was assessed by the affected pedigree member method. RESULTS: No linkage of hypertension to this locus could be demonstrated, but statistically significant allelic associations were noted. CONCLUSIONS: HSD11B2 does not have a strong influence on the development of essential hypertension in Black people, but weaker effects on blood pressure cannot be ruled out.
AB - OBJECTIVE: The HSD11B2 (HSD11K) gene encoding the kidney isozyme of 11β-hydroxysteroid dehydrogenase is mutated in the syndrome of apparent mineralocorticoid excess, an autosomal recessive form of salt-sensitive hypertension. This gene is thus a logical candidate locus for risk of essential hypertension. DESIGN AND METHODS: Because hypertension in Black people tends to be of the low-renin, salt sensitive type, we genotyped independent sets of hypertensives of Afro-American (59 kindreds) and Afro-Caribbean (66 kindreds) origin using a highly polymorphic (heterozygosity index 0.84) CA repeat polymorphism in the first intron of HSD11B2. Linkage was assessed by the affected pedigree member method. RESULTS: No linkage of hypertension to this locus could be demonstrated, but statistically significant allelic associations were noted. CONCLUSIONS: HSD11B2 does not have a strong influence on the development of essential hypertension in Black people, but weaker effects on blood pressure cannot be ruled out.
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U2 - 10.1046/j.1365-2265.2001.01314.x
DO - 10.1046/j.1365-2265.2001.01314.x
M3 - Article
C2 - 11531933
AN - SCOPUS:0034832784
SN - 0300-0664
VL - 55
SP - 249
EP - 252
JO - Clinical Endocrinology
JF - Clinical Endocrinology
IS - 2
ER -