TY - JOUR
T1 - Posing the question again
T2 - Does chronic uric acid nephropathy exist?
AU - Moe, Orson W.
PY - 2010/3
Y1 - 2010/3
N2 - The question of whether hyperuricemia can induce chronic direct renal injury has been argued for many decades. Despite continued efforts and strong motivations to seek an answer, the current evidence still cannot definitively prove or refute the hypothesis. Recent data in rodents do favor causality between hyperuricemia and renal disease. Human epidemiologic data are quite varied, but positive studies do exist. Pathophysiologic models of biology for this entity are sparse in animals and nonexistent in humans.
AB - The question of whether hyperuricemia can induce chronic direct renal injury has been argued for many decades. Despite continued efforts and strong motivations to seek an answer, the current evidence still cannot definitively prove or refute the hypothesis. Recent data in rodents do favor causality between hyperuricemia and renal disease. Human epidemiologic data are quite varied, but positive studies do exist. Pathophysiologic models of biology for this entity are sparse in animals and nonexistent in humans.
UR - http://www.scopus.com/inward/record.url?scp=77949877477&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77949877477&partnerID=8YFLogxK
U2 - 10.1681/ASN.2008101115
DO - 10.1681/ASN.2008101115
M3 - Comment/debate
C2 - 19729442
AN - SCOPUS:77949877477
SN - 1046-6673
VL - 21
SP - 395
EP - 397
JO - Journal of the American Society of Nephrology
JF - Journal of the American Society of Nephrology
IS - 3
ER -