TY - JOUR
T1 - Portable all-fiber dual-output widely tunable light source for coherent Raman imaging
AU - Brinkmann, Maximilian
AU - Fast, Alexander
AU - Hellwig, Tim
AU - Pence, Isaac
AU - Evans, Conor L.
AU - Fallnich, Carsten
N1 - Funding Information:
We acknowledge funding via the EXIST program (Exist-FT 03EFLNW192) of the federal German Ministry for Economic Affairs and Energy and the European Social Fund. Support for this project came from the Laser Biomedical Research Center through an NIH NIBIB P41 grant (2P41EB015871-31). We would like to acknowledge BioPharmX Inc. for providing the human facial skin tissue. We would like to further acknowledge LEO Pharma for providing the ruxolitinib.
Funding Information:
Bundesministerium f?r Wirtschaft und Energie (BMWi); European Social Fund (ESF) (Exist-FT 03EFLNW192)); Laser Biomedical Research Center (2P41EB015871-31, NIH NIBIB P41).
Publisher Copyright:
© 2019 OSA - The Optical Society. All rights reserved.
PY - 2019/9/1
Y1 - 2019/9/1
N2 - We present a rapidly tunable dual-output all-fiber light source for coherent Raman imaging, based on a dispersively matched mode-locked laser pumping a parametric oscillator. Output pump and Stokes pulses with a maximal power of 170 and 400 mW, respectively, and equal durations of 7 ps could be generated. The tuning mechanism required no mechanical delay line, enabling all-electronic arbitrary wavelength switching across more than 2700 cm−1 in less than 5 ms. The compact setup showed a reliable operation despite mechanical shocks of more than 25 m/s2 and is, thus, well suited for operation in a mobile cart. Imaging mouse and human skin tissue with both the portable light source and a commercial laboratory-bound reference system yielded qualitatively equal results and verified the portable light source being well suited for coherent Raman microscopy.
AB - We present a rapidly tunable dual-output all-fiber light source for coherent Raman imaging, based on a dispersively matched mode-locked laser pumping a parametric oscillator. Output pump and Stokes pulses with a maximal power of 170 and 400 mW, respectively, and equal durations of 7 ps could be generated. The tuning mechanism required no mechanical delay line, enabling all-electronic arbitrary wavelength switching across more than 2700 cm−1 in less than 5 ms. The compact setup showed a reliable operation despite mechanical shocks of more than 25 m/s2 and is, thus, well suited for operation in a mobile cart. Imaging mouse and human skin tissue with both the portable light source and a commercial laboratory-bound reference system yielded qualitatively equal results and verified the portable light source being well suited for coherent Raman microscopy.
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U2 - 10.1364/BOE.10.004437
DO - 10.1364/BOE.10.004437
M3 - Article
C2 - 31565500
AN - SCOPUS:85078775300
SN - 2156-7085
VL - 10
SP - 4437
EP - 4449
JO - Biomedical Optics Express
JF - Biomedical Optics Express
IS - 9
ER -