Porcine skin ED50 damage thresholds for 1214 nm laser irradiation

Bo Chen, Jeffrey Oliver, Rebecca Vincelette, Ginger Pocock, Raiyan Zaman, Ashley J. Welch

Research output: Chapter in Book/Report/Conference proceedingConference contribution

6 Scopus citations


A series of experiments were conducted in vivo on porcine skin to determine the ED50 damage thresholds for 1214 nm continuous wave laser irradiation. These results provide new information for refinement of Maximum Permissible Exposure (MPE). The study employed exposure durations of 1 sec, 3 sec, and 10 seconds with nominal spot diameters of 6 mm, 8 mm and 10 mm and as a function of laser power. The effect of each irradiation was evaluated acutely, one hour after exposure, and 24 hours post exposure. Probit analysis was conducted to estimate the dose for 50% probability of laser-induced damage (ED50); Damage was defined as persistent redness at the site of irradiation for the pig skin after 24 hours. The results indicated that Maximum Permissible Exposure (MPE) limits should be lowered for the laser beam diameters larger than 6 mm.

Original languageEnglish (US)
Title of host publicationOptical Interactions with Tissue and Cells XIX
StatePublished - 2008
Externally publishedYes
EventOptical Interactions with Tissue and Cells XIX - San Jose, CA, United States
Duration: Jan 21 2008Jan 23 2008

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
ISSN (Print)1605-7422


ConferenceOptical Interactions with Tissue and Cells XIX
Country/TerritoryUnited States
CitySan Jose, CA

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Atomic and Molecular Physics, and Optics
  • Biomaterials
  • Radiology Nuclear Medicine and imaging


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