TY - JOUR
T1 - Poorly differentiated neuroendocrine carcinoma of the head and neck
T2 - human papillomavirus tumour status/p16 status and impact on overall survival
AU - Benzerdjeb, Nazim
AU - Traverse-Glehen, Alexandra
AU - Philouze, Pierre
AU - Bishop, Justin
AU - Devouassoux-Shisheboran, Mojgan
N1 - Publisher Copyright:
© 2019 John Wiley & Sons Ltd
PY - 2020/3/1
Y1 - 2020/3/1
N2 - Aims: Poorly differentiated neuroendocrine carcinoma (PDNEC) of the head and neck is a rare high-grade neuroendocrine neoplasm. Human papillomavirus (HPV) status and p16 status are as yet unclear among PDNECs, owing to a lack of statistical analysis. The objective of the present study was therefore to evaluate their potential clinicopathological associations, and their prognostic impact on overall survival in PDNECs of the head and neck, regardless to HPV genotype. Methods and results: All cases of PDNEC of the head and neck between 1998 and 2019 were identified from the database of the Lyon university hospital pathology department (n = 21); for these cases, p16 immunohistochemistry and HPV in-situ hybridisation were performed. Published cases of PDNEC of the head and neck with assessment of HPV status and p16 status were identified in PubMed (n = 57). Local and published cases were pooled for analysis. HPV positive (HPV+) tumour status was found to be significantly associated with oropharyngeal localisation (P < 0.001) and overexpression of p16 (P < 0.001). Multivariate analysis, adjusted on tumour site, histological subtype, p16 status, HPV status, and source of the case, showed that oropharyngeal localisation [hazard ratio (HR) 3.031, 95% confidence interval (CI) 1.257–7.310] and being a small-cell variant (HR 2.859, 95% CI 1.150–7.109) were significant predictors of worse overall survival; HPV+ tumour status was associated with better overall survival (HR 0.388, 95% CI 0.146–0.995). Conclusions: HPV+ tumour status was associated with oropharyngeal PDNECs and with a better prognosis.
AB - Aims: Poorly differentiated neuroendocrine carcinoma (PDNEC) of the head and neck is a rare high-grade neuroendocrine neoplasm. Human papillomavirus (HPV) status and p16 status are as yet unclear among PDNECs, owing to a lack of statistical analysis. The objective of the present study was therefore to evaluate their potential clinicopathological associations, and their prognostic impact on overall survival in PDNECs of the head and neck, regardless to HPV genotype. Methods and results: All cases of PDNEC of the head and neck between 1998 and 2019 were identified from the database of the Lyon university hospital pathology department (n = 21); for these cases, p16 immunohistochemistry and HPV in-situ hybridisation were performed. Published cases of PDNEC of the head and neck with assessment of HPV status and p16 status were identified in PubMed (n = 57). Local and published cases were pooled for analysis. HPV positive (HPV+) tumour status was found to be significantly associated with oropharyngeal localisation (P < 0.001) and overexpression of p16 (P < 0.001). Multivariate analysis, adjusted on tumour site, histological subtype, p16 status, HPV status, and source of the case, showed that oropharyngeal localisation [hazard ratio (HR) 3.031, 95% confidence interval (CI) 1.257–7.310] and being a small-cell variant (HR 2.859, 95% CI 1.150–7.109) were significant predictors of worse overall survival; HPV+ tumour status was associated with better overall survival (HR 0.388, 95% CI 0.146–0.995). Conclusions: HPV+ tumour status was associated with oropharyngeal PDNECs and with a better prognosis.
KW - HPV-related poorly differentiated neuroendocrine carcinoma
KW - head and neck
KW - neuroendocrine carcinoma
KW - oropharynx
KW - p16 staining
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U2 - 10.1111/his.13982
DO - 10.1111/his.13982
M3 - Article
C2 - 31463946
AN - SCOPUS:85078762405
SN - 0309-0167
VL - 76
SP - 581
EP - 591
JO - Histopathology
JF - Histopathology
IS - 4
ER -