Polyvalent carbocyanine molecular beacons for molecular recognitions

Yunpeng Ye, Sharon Bloch, Samuel Achilefu

Research output: Contribution to journalArticlepeer-review

9 Scopus citations


Polyvalent carboxylate-terminating near-infrared (NIR) carbocyanine molecular beacons were prepared by homologation of reactive carboxyl groups of the beacon with imino diacetic acid. Their conjugation with unprotected d-(+)-glucosamine gave dendritic arrays of the carbohydrate on an inner NIR chromophore core. In vivo evaluation of the dendritic glucosamine constructs shows enhanced uptake in proliferating tumor cells relative to surrounding normal tissue. The structural framework of these polyvalent beacons permits the amplification by synergistic effects of a variety of bioactive motifs or chemical sensors in molecular recognition interactions without dramatic change of their desirable NIR spectral properties.

Original languageEnglish (US)
Pages (from-to)7740-7741
Number of pages2
JournalJournal of the American Chemical Society
Issue number25
StatePublished - Jun 30 2004
Externally publishedYes

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry


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