Polypeptide transfer from Hsp40 to Hsp70 molecular chaperones

Daniel W. Summers, Peter M. Douglas, Carlos H.I. Ramos, Douglas M. Cyr

Research output: Contribution to journalShort surveypeer-review

63 Scopus citations


Heat shock protein 40 (Hsp40) co-chaperones assist in cellular protein folding and degradation through the binding and delivery of non-native proteins to heat shock protein 70 (Hsp70). The mechanism for substrate transfer from Hsp40s to Hsp70 is unknown. Two recent studies provide new details that shed light on novel mechanisms for substrate recognition by Hsp40s and a common mechanism for polypeptide transfer to Hsp70.

Original languageEnglish (US)
Pages (from-to)230-233
Number of pages4
JournalTrends in biochemical sciences
Issue number5
StatePublished - May 2009

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology


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