Polymorphism in the RD (D6S45) gene

Perrin C. White; Jiri Vitek; Robert G. Lahita; Phyllis W. Speiser

doi:10.1007/BF00217132

Polymorphism in the RD (D6S45) gene

Perrin C. White, Jiri Vitek, Robert G. Lahita, Phyllis W. Speiser

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2 Scopus citations

Abstract

The RD (D6S45) gene in the class III region of the HLA major histocompatibility complex encodes a protein normally containing 24 consecutive basic-acidic dipeptide repeats. We determined the frequency of variations in the number of repeats by use of the polymerase chain reaction. Of 107 subjects 7 (3.3%) carried genes encoding 22 or 23 repeats. There was no difference in the frequency of such polymorphisms between normal individuals and those with systemic lupus erythematosus, a disease associated with other polymorphisms in the class III region of HLA. The frequency of polymorphisms in proteins with oligopeptide repeats may provide useful information concerning functional constraints on repeat number.

Original language	English (US)
Pages (from-to)	243-244
Number of pages	2
Journal	Human genetics
Volume	89
Issue number	2
DOIs	https://doi.org/10.1007/BF00217132
State	Published - May 1992

ASJC Scopus subject areas

Genetics
Genetics(clinical)

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title = "Polymorphism in the RD (D6S45) gene",

abstract = "The RD (D6S45) gene in the class III region of the HLA major histocompatibility complex encodes a protein normally containing 24 consecutive basic-acidic dipeptide repeats. We determined the frequency of variations in the number of repeats by use of the polymerase chain reaction. Of 107 subjects 7 (3.3%) carried genes encoding 22 or 23 repeats. There was no difference in the frequency of such polymorphisms between normal individuals and those with systemic lupus erythematosus, a disease associated with other polymorphisms in the class III region of HLA. The frequency of polymorphisms in proteins with oligopeptide repeats may provide useful information concerning functional constraints on repeat number.",

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AU - White, Perrin C.

AU - Vitek, Jiri

AU - Lahita, Robert G.

AU - Speiser, Phyllis W.

PY - 1992/5

Y1 - 1992/5

N2 - The RD (D6S45) gene in the class III region of the HLA major histocompatibility complex encodes a protein normally containing 24 consecutive basic-acidic dipeptide repeats. We determined the frequency of variations in the number of repeats by use of the polymerase chain reaction. Of 107 subjects 7 (3.3%) carried genes encoding 22 or 23 repeats. There was no difference in the frequency of such polymorphisms between normal individuals and those with systemic lupus erythematosus, a disease associated with other polymorphisms in the class III region of HLA. The frequency of polymorphisms in proteins with oligopeptide repeats may provide useful information concerning functional constraints on repeat number.

AB - The RD (D6S45) gene in the class III region of the HLA major histocompatibility complex encodes a protein normally containing 24 consecutive basic-acidic dipeptide repeats. We determined the frequency of variations in the number of repeats by use of the polymerase chain reaction. Of 107 subjects 7 (3.3%) carried genes encoding 22 or 23 repeats. There was no difference in the frequency of such polymorphisms between normal individuals and those with systemic lupus erythematosus, a disease associated with other polymorphisms in the class III region of HLA. The frequency of polymorphisms in proteins with oligopeptide repeats may provide useful information concerning functional constraints on repeat number.

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Polymorphism in the RD (D6S45) gene

Abstract

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