TY - JOUR
T1 - Polygenic control of susceptibility to murine systemic lupus erythematosus
AU - Morel, Laurence
AU - Rudofsky, Ulrich H.
AU - Longmate, Jeffrey A.
AU - Schiffenbauer, Joel
AU - Wakeland, Edward K.
N1 - Publisher Copyright:
Copyright © 1994 by Cell Press.
PY - 2015/11
Y1 - 2015/11
N2 - Susceptibility to glomerulonephritis (GN) and anti-dsDNA autoantibody production was analyzed in crosses with a newly developed systemic lupus erythematosus-susceptible inbred strain, MZM/Aeg2410. The mode of inheritance and the number and location of systemic lupus erythematosus-associated susceptibility loci were analyzed by interval mapping in a backcross with C57BL/6. Three chromosomal intervals containing strong recessive GM susceptibility alleles were identified on chromosomes 1, 4, and 7, each containing several potentially interesting candidate genes. Heterozygosity at H-2 was also found to correlate strongly with GN susceptibility, consistent with previous findings in the NZB/NZW parental strain model. Logistic regression analysis indicated that each of these susceptibility alleles independently accounted for a component of GN susceptibility, and that susceptibility was inherited as a threshold genetic liability in this model system.
AB - Susceptibility to glomerulonephritis (GN) and anti-dsDNA autoantibody production was analyzed in crosses with a newly developed systemic lupus erythematosus-susceptible inbred strain, MZM/Aeg2410. The mode of inheritance and the number and location of systemic lupus erythematosus-associated susceptibility loci were analyzed by interval mapping in a backcross with C57BL/6. Three chromosomal intervals containing strong recessive GM susceptibility alleles were identified on chromosomes 1, 4, and 7, each containing several potentially interesting candidate genes. Heterozygosity at H-2 was also found to correlate strongly with GN susceptibility, consistent with previous findings in the NZB/NZW parental strain model. Logistic regression analysis indicated that each of these susceptibility alleles independently accounted for a component of GN susceptibility, and that susceptibility was inherited as a threshold genetic liability in this model system.
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M3 - Article
C2 - 26477047
AN - SCOPUS:84945151325
SN - 0022-1767
VL - 195
SP - 4047
EP - 4057
JO - Journal of Immunology
JF - Journal of Immunology
IS - 9
ER -