Polydopamine nanoparticles and hyaluronic acid hydrogels for mussel-inspired tissue adhesive nanocomposites

Nikhil Pandey, Luis Soto-Garcia, Serkan Yaman, Aneetta Kuriakose, Andres Urias Rivera, Valinda Jones, Jun Liao, Philippe Zimmern, Kytai T. Nguyen, Yi Hong

Research output: Contribution to journalArticlepeer-review

17 Scopus citations


Bioadhesives are intended to facilitate the fast and efficient reconnection of tissues to restore their functionality after surgery or injury. The use of mussel-inspired hydrogel systems containing pendant catechol moieties is promising for tissue attachment under wet conditions. However, the adhesion strength is not yet ideal. One way to overcome these limitations is to add polymeric nanoparticles to create nanocomposites with improved adhesion characteristics. To further enhance adhesiveness, polydopamine nanoparticles with controlled size prepared using an optimized process, were combined with a mussel-inspired hyaluronic acid (HA) hydrogel to form a nanocomposite. The effects of sizes and concentrations of polydopamine nanoparticles on the adhesive profiles of mussel-inspired HA hydrogels were investigated. Results show that the inclusion of polydopamine nanoparticles in nanocomposites increased adhesion strength, as compared to the addition of poly (lactic-co-glycolic acid) (PLGA), and PLGA-(N-hydroxysuccinimide) (PLGA-NHS) nanoparticles. A nanocomposite with demonstrated cytocompatibility and an optimal lap shear strength (47 ± 3 kPa) was achieved by combining polydopamine nanoparticles of 200 nm (12.5% w/v) with a HA hydrogel (40% w/v). This nanocomposite adhesive shows its potential as a tissue glue for biomedical applications.

Original languageEnglish (US)
Article number112589
JournalMaterials Science and Engineering C
StateAccepted/In press - 2021


  • Bioadhesives
  • Hyaluronic acid
  • Nanocomposites
  • Nanoparticles
  • Polydopamine

ASJC Scopus subject areas

  • General Medicine


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