TY - JOUR
T1 - Polyamines in eukaryotes, bacteria, and archaea
AU - Michael, Anthony J.
N1 - Publisher Copyright:
© 2016 by The American Society for Biochemistry and Molecular Biology, Inc.
PY - 2016/7/15
Y1 - 2016/7/15
N2 - Polyamines are primordial polycations found in most cells and perform different functions in different organisms. Although polyamines are mainly known for their essential roles in cell growth and proliferation, their functions range from a critical role in cellular translation in eukaryotes and archaea, to bacterial biofilm formation and specialized roles in natural product biosynthesis. At first glance, the diversity of polyamine structures in different organisms appears chaotic; however, biosynthetic flexibility and evolutionary and ecological processes largely explain this heterogeneity. In this review, I discuss the biosynthetic, evolutionary, and physiological processes that constrain or expand polyamine structural and functional diversity.
AB - Polyamines are primordial polycations found in most cells and perform different functions in different organisms. Although polyamines are mainly known for their essential roles in cell growth and proliferation, their functions range from a critical role in cellular translation in eukaryotes and archaea, to bacterial biofilm formation and specialized roles in natural product biosynthesis. At first glance, the diversity of polyamine structures in different organisms appears chaotic; however, biosynthetic flexibility and evolutionary and ecological processes largely explain this heterogeneity. In this review, I discuss the biosynthetic, evolutionary, and physiological processes that constrain or expand polyamine structural and functional diversity.
UR - http://www.scopus.com/inward/record.url?scp=84978902250&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84978902250&partnerID=8YFLogxK
U2 - 10.1074/jbc.R116.734780
DO - 10.1074/jbc.R116.734780
M3 - Review article
C2 - 27268252
AN - SCOPUS:84978902250
SN - 0021-9258
VL - 291
SP - 14896
EP - 14903
JO - Journal of Biological Chemistry
JF - Journal of Biological Chemistry
IS - 29
ER -