TY - JOUR
T1 - Pneumococcal Surface Protein C Contributes to Sepsis Caused by Streptococcus pneumoniae in Mice
AU - Iannelli, Francesco
AU - Chiavolini, Damiana
AU - Ricci, Susanna
AU - Oggioni, Marco Rinaldo
AU - Pozzi, Gianni
PY - 2004/5
Y1 - 2004/5
N2 - The role of pneumococcal surface protein C (PspC; also called SpsA, CbpA, and Hic) in sepsis by Streptococcus pneumoniae was investigated in a murine infection model. The pspC gene was deleted in strains D39 (type 2) and A66 (type 3), and the mutants were tested by being injected intravenously into mice. The animals infected with the mutant strains showed a significant increase in survival, with the 50% lethal dose up to 250-fold higher than that for the wild type. Our findings indicate that PspC affords a decisive contribution to sepsis development.
AB - The role of pneumococcal surface protein C (PspC; also called SpsA, CbpA, and Hic) in sepsis by Streptococcus pneumoniae was investigated in a murine infection model. The pspC gene was deleted in strains D39 (type 2) and A66 (type 3), and the mutants were tested by being injected intravenously into mice. The animals infected with the mutant strains showed a significant increase in survival, with the 50% lethal dose up to 250-fold higher than that for the wild type. Our findings indicate that PspC affords a decisive contribution to sepsis development.
UR - http://www.scopus.com/inward/record.url?scp=2142646463&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=2142646463&partnerID=8YFLogxK
U2 - 10.1128/IAI.72.5.3077-3080.2004
DO - 10.1128/IAI.72.5.3077-3080.2004
M3 - Article
C2 - 15102826
AN - SCOPUS:2142646463
SN - 0019-9567
VL - 72
SP - 3077
EP - 3080
JO - Infection and immunity
JF - Infection and immunity
IS - 5
ER -