Platelet [3H]-imipramine binding and leukoencephalopathy in geriatric depression

Mustafa M. Husain, David L. Knight, P. Murali Doraiswamy, Gary S. Figiel, William M. McDonald, Orest B. Boyko, K. Ranga, R. Krishnan, Charles B. Nemeroff

Research output: Contribution to journalArticlepeer-review

11 Scopus citations


We examined the relationship between platelet [3H]-imipramine binding and leukoencephalopathy as assessed by 1.5 Tesla Magnetic Resonance Imaging (MRI) in 21 elderly depressed patients who satisfied DSM-III criteria for major depression. Both drug-free platelet [3H]-imipramine binding and brain MRI studies were obtained during the same episode of depression. Our findings show a significant inverse relationship between frequency of subcortical hyperintensity (SCH) and the number (Bmax of platelet [3H]-imipramine binding sites. Patients with Bmax less than 850 fmol/mg protein had significantly larger SCH compared with patients with a higher Bmax. These data provide further support to the potential use of platelet [3H]-imipramine binding studies and brain MR imaging as diagnostic adjuncts in geriatric depression and suggest, moreover, that these two biological markers may be linked in geriatric patients with depression.

Original languageEnglish (US)
Pages (from-to)665-670
Number of pages6
JournalBiological Psychiatry
Issue number7
StatePublished - Apr 1 1991

ASJC Scopus subject areas

  • Biological Psychiatry


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