Platelet perturbations in diabetes: Implications for cardiovascular disease risk and treatment

Shiny Mathewkutty, Darren K McGuire

Research output: Contribution to journalReview articlepeer-review

11 Scopus citations


The prevalence of Type 2 diabetes mellitus (DM) continues to increase globally and brings with it a parallel increase in the associated cardiovascular disease complications. Despite advances in evidence-based therapies for cardiovascular disease risk modification, many of which are especially effective among patients with DM, there remains a residual degree of cardiovascular disease risk associated with DM, yielding opportunity for continued clinical advances. Given the myriad perturbations of platelet function associated with DM, improvements in antiplatelet therapies hold particular promise for this high-risk population of patients, with emerging data from ex vivo assessments and clinical outcomes trials providing a basis of support for this concept.

Original languageEnglish (US)
Pages (from-to)541-549
Number of pages9
JournalExpert Review of Cardiovascular Therapy
Issue number5
StatePublished - May 2009


  • Antiplatelet therapy
  • Cardiovascular disease
  • Diabetes mellitus

ASJC Scopus subject areas

  • Internal Medicine
  • Cardiology and Cardiovascular Medicine


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