Plasma renin and risk of cardiovascular disease and mortality: The Framingham Heart Study

Nisha I. Parikh, Philimon Gona, Martin G. Larson, Thomas J. Wang, Christopher Newton-Cheh, Daniel Levy, Emelia J. Benjamin, William B. Kannel, Ramachandran S. Vasan

Research output: Contribution to journalArticlepeer-review

52 Scopus citations


Aims: Previous studies relating plasma renin to cardiovascular disease (CVD) and mortality yielded conflicting results. We related plasma renin to incidence of CVD and mortality in 3408 individuals (mean age 59; 53% women) and in a hypertensive subset (n = 1413). Methods and results: On follow-up (mean 7.1 years), 176 participants (122 hypertensives) developed CVD and 215 individuals (127 hypertensives) died. Overall, log-renin was associated with mortality [multivariable-adjusted hazards ratio (HR) per SD increment: in whole sample, 1.14, 95% confidence interval (CI) 1.00-1.30, P = 0.046; hypertensives, 1.16, 95% CI 1.00-1.35, P = 0.046], but relations varied over time (P < 0.02). Log-renin was associated with mortality at 2.5 years of follow-up (HR per SD increment: whole sample at 2.5 years, 1.23, 95% CI 1.04-1.45; hypertensives at 2 years, 1.28, 95% CI 1.06-1.54), but not during longer follow-up (HR per SD increment at 5 years: whole sample, 1.02, 95% CI 0.80-1.29; hypertensives, 0.98, 95% CI 0.74-1.30). The time-dependent relation of renin and mortality risk was maintained upon excluding participants with prevalent CVD. Renin was not associated with CVD incidence (HR per SD increment log-renin: whole sample, 0.99, 95% CI 0.85-1.14; hypertensives, 0.96, 95% CI 0.82-1.12). Conclusion: Higher plasma renin was associated with greater short-term mortality but not with CVD incidence in the community.

Original languageEnglish (US)
Pages (from-to)2644-2652
Number of pages9
JournalEuropean heart journal
Issue number21
StatePublished - Nov 2007
Externally publishedYes


  • All-cause mortality
  • Cardiovascular disease
  • Epidemiology
  • Hypertension
  • Renin

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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