TY - JOUR
T1 - Plasma choline concentrations in children requiring long-term home parenteral nutrition
T2 - A case control study
AU - Misra, Sudipta
AU - Ahn, Chul
AU - Ament, Marvin E.
AU - Choi, Ha Joo
AU - Jenden, Donald J.
AU - Roch, Margareth
AU - Buchman, Alan L.
PY - 1999
Y1 - 1999
N2 - Background: Low plasma free choline concentration has been associated with elevated serum hepatic aminotransferase concentrations and hepatic steatosis in adults who need home parenteral nutrition (HPN). We sought to determine if plasma free choline is similarly reduced in children who need home total parenteral nutrition (TPN). Methods: We compared the plasma free choline concentration in 21 children who required long-term HPN with 31 normal controls. Patients had received HPN for 75 ± 13 (SD) months (range 3- 206 months). All control children ingested a normal, mixed, nonvegetarian diet. Results: The mean plasma free choline concentration in the children receiving HPN was significantly lower than normal children (6.6 ± 4.3 vs 8.0 ± 2.3 nmol/mL, p = .002). Plasma free choline concentration was correlated with age (r = -0.43, p = .049). Using multiple linear regression analysis for age, sex, and squared age (considered in order to account for possible nonlinearity between choline and age), HPN children showed a steady and significant decline in plasma free choline concentration with increased age at the rate of 0.03 nmol/mL per month. Plasma lipid bound choline concentration did not vary with age. No relationship was seen between either plasma free and lipid bound choline concentration and amount of daily IV lipid infusion. A significant negative correlation was observed between plasma free choline concentration and aspartate aminotransferase (AST) and alanine aminostransferase (ALT) (r = -0.72, p = .04 and r = -0.80, p = .02, respectively). Conclusion: Our data support the notion that patients who need long-term HPN without significant enteral feeding have a significant risk for the development of choline deficiency with its associated hepatic dysfunction.
AB - Background: Low plasma free choline concentration has been associated with elevated serum hepatic aminotransferase concentrations and hepatic steatosis in adults who need home parenteral nutrition (HPN). We sought to determine if plasma free choline is similarly reduced in children who need home total parenteral nutrition (TPN). Methods: We compared the plasma free choline concentration in 21 children who required long-term HPN with 31 normal controls. Patients had received HPN for 75 ± 13 (SD) months (range 3- 206 months). All control children ingested a normal, mixed, nonvegetarian diet. Results: The mean plasma free choline concentration in the children receiving HPN was significantly lower than normal children (6.6 ± 4.3 vs 8.0 ± 2.3 nmol/mL, p = .002). Plasma free choline concentration was correlated with age (r = -0.43, p = .049). Using multiple linear regression analysis for age, sex, and squared age (considered in order to account for possible nonlinearity between choline and age), HPN children showed a steady and significant decline in plasma free choline concentration with increased age at the rate of 0.03 nmol/mL per month. Plasma lipid bound choline concentration did not vary with age. No relationship was seen between either plasma free and lipid bound choline concentration and amount of daily IV lipid infusion. A significant negative correlation was observed between plasma free choline concentration and aspartate aminotransferase (AST) and alanine aminostransferase (ALT) (r = -0.72, p = .04 and r = -0.80, p = .02, respectively). Conclusion: Our data support the notion that patients who need long-term HPN without significant enteral feeding have a significant risk for the development of choline deficiency with its associated hepatic dysfunction.
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U2 - 10.1177/0148607199023005305
DO - 10.1177/0148607199023005305
M3 - Article
C2 - 10485444
AN - SCOPUS:0033501277
SN - 0148-6071
VL - 23
SP - 305
EP - 308
JO - Journal of Parenteral and Enteral Nutrition
JF - Journal of Parenteral and Enteral Nutrition
IS - 5
ER -