Placental pathology associated with lenticulostriate vasculopathy (LSV) in preterm infants

Julide Sisman; Rachel L. Leon; Brooke W. Payton; L. Steven Brown; Imran N. Mir

doi:10.1038/s41372-022-01557-5

Placental pathology associated with lenticulostriate vasculopathy (LSV) in preterm infants

Julide Sisman, Rachel L. Leon, Brooke W. Payton, L. Steven Brown, Imran N. Mir

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

Objective: Our aim was to examine the frequency and type of placental abnormalities in neonates with LSV. Study design: We prospectively reviewed cranial ultrasounds (cUS) from neonates born at ≤32 weeks of gestation at Parkland Hospital between 2012 and 2014. Our cohort included neonates with LSV and gestational age and sex matched controls with normal cUS. We retrieved placental pathology reports retrospectively and compared placental abnormalities in both groups. Results: We reviewed 1351 cUS from a total of 407 neonates. Placental pathology evaluations were complete for 64/65 (98%) neonates with LSV and 68/70 (97%) matched controls. There were no significant differences for any type of placental abnormities between LSV and control groups. However, infants with highest stage LSV were more likely to have large for gestational age (LGA) placentas (p = 0.01). Conclusion: The association between LSV and LGA placenta may indicate a shared vascular response to an adverse prenatal environment.

Original language	English (US)
Pages (from-to)	568-572
Number of pages	5
Journal	Journal of Perinatology
Volume	43
Issue number	5
DOIs	https://doi.org/10.1038/s41372-022-01557-5
State	Published - May 2023

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Obstetrics and Gynecology

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10.1038/s41372-022-01557-5

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title = "Placental pathology associated with lenticulostriate vasculopathy (LSV) in preterm infants",

abstract = "Objective: Our aim was to examine the frequency and type of placental abnormalities in neonates with LSV. Study design: We prospectively reviewed cranial ultrasounds (cUS) from neonates born at ≤32 weeks of gestation at Parkland Hospital between 2012 and 2014. Our cohort included neonates with LSV and gestational age and sex matched controls with normal cUS. We retrieved placental pathology reports retrospectively and compared placental abnormalities in both groups. Results: We reviewed 1351 cUS from a total of 407 neonates. Placental pathology evaluations were complete for 64/65 (98%) neonates with LSV and 68/70 (97%) matched controls. There were no significant differences for any type of placental abnormities between LSV and control groups. However, infants with highest stage LSV were more likely to have large for gestational age (LGA) placentas (p = 0.01). Conclusion: The association between LSV and LGA placenta may indicate a shared vascular response to an adverse prenatal environment.",

author = "Julide Sisman and Leon, {Rachel L.} and Payton, {Brooke W.} and Brown, {L. Steven} and Mir, {Imran N.}",

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T1 - Placental pathology associated with lenticulostriate vasculopathy (LSV) in preterm infants

AU - Sisman, Julide

AU - Leon, Rachel L.

AU - Payton, Brooke W.

AU - Brown, L. Steven

AU - Mir, Imran N.

PY - 2023/5

Y1 - 2023/5

N2 - Objective: Our aim was to examine the frequency and type of placental abnormalities in neonates with LSV. Study design: We prospectively reviewed cranial ultrasounds (cUS) from neonates born at ≤32 weeks of gestation at Parkland Hospital between 2012 and 2014. Our cohort included neonates with LSV and gestational age and sex matched controls with normal cUS. We retrieved placental pathology reports retrospectively and compared placental abnormalities in both groups. Results: We reviewed 1351 cUS from a total of 407 neonates. Placental pathology evaluations were complete for 64/65 (98%) neonates with LSV and 68/70 (97%) matched controls. There were no significant differences for any type of placental abnormities between LSV and control groups. However, infants with highest stage LSV were more likely to have large for gestational age (LGA) placentas (p = 0.01). Conclusion: The association between LSV and LGA placenta may indicate a shared vascular response to an adverse prenatal environment.

AB - Objective: Our aim was to examine the frequency and type of placental abnormalities in neonates with LSV. Study design: We prospectively reviewed cranial ultrasounds (cUS) from neonates born at ≤32 weeks of gestation at Parkland Hospital between 2012 and 2014. Our cohort included neonates with LSV and gestational age and sex matched controls with normal cUS. We retrieved placental pathology reports retrospectively and compared placental abnormalities in both groups. Results: We reviewed 1351 cUS from a total of 407 neonates. Placental pathology evaluations were complete for 64/65 (98%) neonates with LSV and 68/70 (97%) matched controls. There were no significant differences for any type of placental abnormities between LSV and control groups. However, infants with highest stage LSV were more likely to have large for gestational age (LGA) placentas (p = 0.01). Conclusion: The association between LSV and LGA placenta may indicate a shared vascular response to an adverse prenatal environment.

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Placental pathology associated with lenticulostriate vasculopathy (LSV) in preterm infants

Abstract

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