Placental contribution to neonatal encephalopathy

Newborn Brain Society Guidelines and Publications Committee

Research output: Contribution to journalReview articlepeer-review

14 Scopus citations


Placental assessment, although currently underused, can inform our understanding of the etiology and timing of Neonatal Encephalopathy (NE). We review our current understanding of the links between placental dysfunction and NE and how this information may inform clinical decisions, now and in the future, emphasizing the four major placental lesions associated with NE. In addition, we discuss maternal and fetal factors that are hypothesized to contribute to specific placental pathologies, especially innate or acquired thrombophilias. We outline the importance of assessing placenta across trimesters and after delivery. As this field continues to evolve, currently available placental histopathological examination methods may need to be combined with advanced prenatal molecular and imaging assessments of placenta and be applied in well-designed studies in large representative populations to better define the links between placental dysfunction and NE.

Original languageEnglish (US)
Article number101276
JournalSeminars in Fetal and Neonatal Medicine
Issue number4
StatePublished - Aug 2021


  • Chorioamnionitis
  • Chronic villitis
  • Fetal vascular malperfusion
  • Histopathology
  • Maternal vascular malperfusion
  • Neonatal encephalopathy
  • Perinatal brain injury
  • Placenta
  • Villitis of unknown etiology

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health


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