TY - JOUR
T1 - Pituitary abnormalities in eating disorders
T2 - Further evidence from MRI studies
AU - Doraiswamy, P. Murali
AU - Krishnan, K. Ranga
AU - Boyko, Orest B.
AU - Husain, Mustafa H.
AU - Figiel, Gary S.
AU - Palese, Vincent J.
AU - Escalona, P. Rodrigo
AU - Shah, Sunjay A.
AU - Mcdonald, William M.
AU - Rockwell, W. J Kenneth
AU - Ellinwood, Everett H.
N1 - Funding Information:
The authors are grateful to Robert A. Burn , Chief Radiology Technician and all the MRI staff for their expert technical assistance, to Lou T. Mallard, Registered Nurse for helping with the patient data, and to Martha Payne, Bachelor Arts and Gary Hadden, Bachelor Science for manuscript preparation. Supported in part by NIGH MIi-42210.
PY - 1991
Y1 - 1991
N2 - Doraiswamy, P. Murali, K. Ranga Krishnan, Orest B. Boyko, Mustafa M. Husain, Gary S. Figiel, Vincent J. Palese P. Rodrigo Escalona, Sunjay A. Shah, William M. McDonald W.J. Kenneth Rockwell, and Everett H. Ellinwood Jr.: Pituitary Abnormalities in Eating Disorders: Further Evidence from MRI Studies. Prog. Neuro-Psychopharmacol. & Biol. Psychiat. 1991, 15:351-356. 1. 1. The frequent occurrence of hypothalamo-pituitary dysfunction in patients with eating disorders as well as prior reports that nutritional and endocrine status influence pituitary morphology, led us to hypothesize that pituitary size and shape may be altered in patients with eating disorders. 2. 2. Magnetic resonance imaging (MRI) does not use ionizing radiation and is currently one of the most feasible modalities available to study the pituitary gland in vivo. Using MRI, we have previously reported in a preliminary study that female patients with eating disorders had significantly smaller pituitary glands than controls. In addition MRI excluded any pituitary mass lesions. 3. 3. In this report, we confirm our previous MRI findings and provide further evidence of pituitary abnormalities In an expanded sample of eating disorder patients. Preliminary data on pituitary volume estimates from MRI scans are provided for a subset of patients arid controls.
AB - Doraiswamy, P. Murali, K. Ranga Krishnan, Orest B. Boyko, Mustafa M. Husain, Gary S. Figiel, Vincent J. Palese P. Rodrigo Escalona, Sunjay A. Shah, William M. McDonald W.J. Kenneth Rockwell, and Everett H. Ellinwood Jr.: Pituitary Abnormalities in Eating Disorders: Further Evidence from MRI Studies. Prog. Neuro-Psychopharmacol. & Biol. Psychiat. 1991, 15:351-356. 1. 1. The frequent occurrence of hypothalamo-pituitary dysfunction in patients with eating disorders as well as prior reports that nutritional and endocrine status influence pituitary morphology, led us to hypothesize that pituitary size and shape may be altered in patients with eating disorders. 2. 2. Magnetic resonance imaging (MRI) does not use ionizing radiation and is currently one of the most feasible modalities available to study the pituitary gland in vivo. Using MRI, we have previously reported in a preliminary study that female patients with eating disorders had significantly smaller pituitary glands than controls. In addition MRI excluded any pituitary mass lesions. 3. 3. In this report, we confirm our previous MRI findings and provide further evidence of pituitary abnormalities In an expanded sample of eating disorder patients. Preliminary data on pituitary volume estimates from MRI scans are provided for a subset of patients arid controls.
KW - MRI
KW - anorexia
KW - bulimia
KW - hypothalamus
KW - pituitary gland
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U2 - 10.1016/0278-5846(91)90066-A
DO - 10.1016/0278-5846(91)90066-A
M3 - Article
C2 - 1862218
AN - SCOPUS:0025845365
SN - 0278-5846
VL - 15
SP - 351
EP - 356
JO - Progress in Neuropsychopharmacology and Biological Psychiatry
JF - Progress in Neuropsychopharmacology and Biological Psychiatry
IS - 3
ER -