TY - JOUR
T1 - Pictures in cell biology structures of nuclear-transport components
AU - Chook, Yuh Min
AU - Cingolani, Gino
AU - Conti, Elena
AU - Stewart, Murray
AU - Vetter, Ingrid
AU - Wittinghofer, Alfred
PY - 1999/8/1
Y1 - 1999/8/1
N2 - The past three years have seen the solution of several nuclear transport component structures and recently of the structure of a regulator bound to part of a nuclear pore complex (NPC) protein. These structures have provided a wealth of valuable information about the proteins involved and suggested strategies for further investigation of their properties. We do not have space here to go into detail about this information, so instead we are illustrating the structures and providing primary references enabling interested readers to find further information. On this page, we are concentrating on the GTPase Ran and proteins that modulate its activity, and on the facing page are other transport factors, some of which also interact directly with Ran. Notably absent at the moment are the nuclear pore complex components, apart from one domain of RanBP2. Only when these are characterized fully will we really be able to understand how transport substrates move across the nuclear envelope.
AB - The past three years have seen the solution of several nuclear transport component structures and recently of the structure of a regulator bound to part of a nuclear pore complex (NPC) protein. These structures have provided a wealth of valuable information about the proteins involved and suggested strategies for further investigation of their properties. We do not have space here to go into detail about this information, so instead we are illustrating the structures and providing primary references enabling interested readers to find further information. On this page, we are concentrating on the GTPase Ran and proteins that modulate its activity, and on the facing page are other transport factors, some of which also interact directly with Ran. Notably absent at the moment are the nuclear pore complex components, apart from one domain of RanBP2. Only when these are characterized fully will we really be able to understand how transport substrates move across the nuclear envelope.
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U2 - 10.1016/S0962-8924(99)01610-4
DO - 10.1016/S0962-8924(99)01610-4
M3 - Short survey
C2 - 10490335
AN - SCOPUS:0033179197
SN - 0962-8924
VL - 9
SP - 310
EP - 311
JO - Trends in Cell Biology
JF - Trends in Cell Biology
IS - 8
ER -