Phototherapy and HIV infection

Hallie McDonald; Ponciano D Cruz

doi:10.1007/978-3-540-36693-5_10

Phototherapy and HIV infection

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

In vitro studies indicate UV radiation activates HIV gene expression. To repair DNA damage caused by UV, cells turn on genes, including HIV genes; however, the overall effect of increased viral load in skin may be insignificant. UV may produce adverse effects by inhibiting TH1 protective immune responses and promoting TH2 tolerogenic immune responses. Phototherapy improves psoriasis, eosinophilic folliculitis, atopic dermatitis, and pruritus in HIV-infected individuals. There is no compelling proof that UVB or PUVA treatment leads to harmful systemic effects in HIV-infected patients.

Original language	English (US)
Title of host publication	Dermatological Phototherapy and Photodiagnostic Methods
Publisher	Springer Berlin Heidelberg
Pages	229-237
Number of pages	9
ISBN (Print)	9783540366928
DOIs	https://doi.org/10.1007/978-3-540-36693-5_10
State	Published - Dec 1 2009

ASJC Scopus subject areas

Medicine(all)

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10.1007/978-3-540-36693-5_10

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abstract = "In vitro studies indicate UV radiation activates HIV gene expression. To repair DNA damage caused by UV, cells turn on genes, including HIV genes; however, the overall effect of increased viral load in skin may be insignificant. UV may produce adverse effects by inhibiting TH1 protective immune responses and promoting TH2 tolerogenic immune responses. Phototherapy improves psoriasis, eosinophilic folliculitis, atopic dermatitis, and pruritus in HIV-infected individuals. There is no compelling proof that UVB or PUVA treatment leads to harmful systemic effects in HIV-infected patients.",

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AB - In vitro studies indicate UV radiation activates HIV gene expression. To repair DNA damage caused by UV, cells turn on genes, including HIV genes; however, the overall effect of increased viral load in skin may be insignificant. UV may produce adverse effects by inhibiting TH1 protective immune responses and promoting TH2 tolerogenic immune responses. Phototherapy improves psoriasis, eosinophilic folliculitis, atopic dermatitis, and pruritus in HIV-infected individuals. There is no compelling proof that UVB or PUVA treatment leads to harmful systemic effects in HIV-infected patients.

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Phototherapy and HIV infection

Abstract

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