Photoreception in Neurospora: A tale of two White Collar proteins

Y. Liu, Q. He, P. Cheng

Research output: Contribution to journalReview articlepeer-review

84 Scopus citations


Neurospora crassa is the best-understood fungal organism in terms of the mechanism of light responses. All known Neurospora photoresponses are mediated by blue light. Two Per-Arnt-Simdomain containing transcription factors, WHITE COLLAR-1 (WC-1) and WC-2, are essential components for almost all light responses. Recently, WC-1 was shown to be a blue-light photoreceptor. How light affects the DNA binding of the WC proteins to the promoter of the circadian clock gene frequency was also demonstrated. These studies established a mechanism that explains the light responses mediated by activation of transcription. The purpose of this review is to summarize the findings of recent studies on the molecular mechanism of photoreception in Neurospora.

Original languageEnglish (US)
Pages (from-to)2131-2138
Number of pages8
JournalCellular and Molecular Life Sciences
Issue number10
StatePublished - Oct 1 2003


  • Blue light photoreceptor
  • Circadian clock
  • Frequency
  • LOV domain
  • Light responses
  • White collar-1

ASJC Scopus subject areas

  • Molecular Medicine
  • Molecular Biology
  • Pharmacology
  • Cellular and Molecular Neuroscience
  • Cell Biology


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