Phosphorus-31 NMR of neuroblastoma clonal lines - Effect of cell confluency state and dibutyryl cyclic AMP

Jay W. Pettegrew; Thomas Glonek; Fred Baskin; Roger N. Rosenberg

doi:10.1007/BF00964475

Phosphorus-31 NMR of neuroblastoma clonal lines - Effect of cell confluency state and dibutyryl cyclic AMP

Jay W. Pettegrew, Thomas Glonek, Fred Baskin, Roger N. Rosenberg

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Abstract

Phosphorus nuclear magnetic resonance is used to study changes in the levels of the major phosphate-containing intermediary metabolites concomitant with induced cellular differentiation in the N-18 and C-46 neuroblastoma clonal lines. The study reveals differences between the³¹P-NMR profiles of the two clonal lines and also striking differences attendant to dibutyryl cAMP-mediated morphological differentiation in the N-18 clone. Phosphorus-31 NMR would appear to provide a new technique with which to study genetic differentiation.

Original language	English (US)
Pages (from-to)	795-802
Number of pages	8
Journal	Neurochemical Research
Volume	4
Issue number	6
DOIs	https://doi.org/10.1007/BF00964475
State	Published - Dec 1 1979

ASJC Scopus subject areas

Biochemistry
Cellular and Molecular Neuroscience

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abstract = "Phosphorus nuclear magnetic resonance is used to study changes in the levels of the major phosphate-containing intermediary metabolites concomitant with induced cellular differentiation in the N-18 and C-46 neuroblastoma clonal lines. The study reveals differences between the31P-NMR profiles of the two clonal lines and also striking differences attendant to dibutyryl cAMP-mediated morphological differentiation in the N-18 clone. Phosphorus-31 NMR would appear to provide a new technique with which to study genetic differentiation.",

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AU - Pettegrew, Jay W.

AU - Glonek, Thomas

AU - Baskin, Fred

AU - Rosenberg, Roger N.

PY - 1979/12/1

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N2 - Phosphorus nuclear magnetic resonance is used to study changes in the levels of the major phosphate-containing intermediary metabolites concomitant with induced cellular differentiation in the N-18 and C-46 neuroblastoma clonal lines. The study reveals differences between the31P-NMR profiles of the two clonal lines and also striking differences attendant to dibutyryl cAMP-mediated morphological differentiation in the N-18 clone. Phosphorus-31 NMR would appear to provide a new technique with which to study genetic differentiation.

AB - Phosphorus nuclear magnetic resonance is used to study changes in the levels of the major phosphate-containing intermediary metabolites concomitant with induced cellular differentiation in the N-18 and C-46 neuroblastoma clonal lines. The study reveals differences between the31P-NMR profiles of the two clonal lines and also striking differences attendant to dibutyryl cAMP-mediated morphological differentiation in the N-18 clone. Phosphorus-31 NMR would appear to provide a new technique with which to study genetic differentiation.

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Phosphorus-31 NMR of neuroblastoma clonal lines - Effect of cell confluency state and dibutyryl cyclic AMP

Abstract

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