Phenotypic and functional consequences of herpesvirus saimiri infection of human CD8+ cytotoxic T lymphocytes

Keith R. Berend; Jae U. Jung; Terence J. Boyle; J. Michael DiMaio; Salvatore A. Mungal; Ronald C. Desrosiers; H. Kim Lyerly

doi:10.1128/jvi.67.10.6317-6321.1993

Phenotypic and functional consequences of herpesvirus saimiri infection of human CD8⁺ cytotoxic T lymphocytes

Keith R. Berend, Jae U. Jung, Terence J. Boyle, J. Michael DiMaio, Salvatore A. Mungal, Ronald C. Desrosiers, H. Kim Lyerly

Cardio Thoracic Surgery

Research output: Contribution to journal › Comment/debate › peer-review

37 Scopus citations

Abstract

Herpesvirus saimiri (HVS) was used to infect and transform human CD8⁺ cytotoxic T lymphocytes (CTL), and the phenotypic and functional consequences of HVS infection of CD8⁺ T lymphocytes were investigated. HVS- transformed CTL no longer require antigen restimulation yet maintain their phenotype and HLA-restricted cytolytic function and specificity. The ability of HVS to transform CTL may have an important role in the functional analysis of human antigen-specific CTL.

Original language	English (US)
Pages (from-to)	6317-6321
Number of pages	5
Journal	Journal of virology
Volume	67
Issue number	10
DOIs	https://doi.org/10.1128/jvi.67.10.6317-6321.1993
State	Published - 1993

ASJC Scopus subject areas

Microbiology
Immunology
Insect Science
Virology

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10.1128/jvi.67.10.6317-6321.1993

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title = "Phenotypic and functional consequences of herpesvirus saimiri infection of human CD8+ cytotoxic T lymphocytes",

abstract = "Herpesvirus saimiri (HVS) was used to infect and transform human CD8+ cytotoxic T lymphocytes (CTL), and the phenotypic and functional consequences of HVS infection of CD8+ T lymphocytes were investigated. HVS- transformed CTL no longer require antigen restimulation yet maintain their phenotype and HLA-restricted cytolytic function and specificity. The ability of HVS to transform CTL may have an important role in the functional analysis of human antigen-specific CTL.",

author = "Berend, {Keith R.} and Jung, {Jae U.} and Boyle, {Terence J.} and DiMaio, {J. Michael} and Mungal, {Salvatore A.} and Desrosiers, {Ronald C.} and Lyerly, {H. Kim}",

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T1 - Phenotypic and functional consequences of herpesvirus saimiri infection of human CD8+ cytotoxic T lymphocytes

AU - Berend, Keith R.

AU - Jung, Jae U.

AU - Boyle, Terence J.

AU - DiMaio, J. Michael

AU - Mungal, Salvatore A.

AU - Desrosiers, Ronald C.

AU - Lyerly, H. Kim

PY - 1993

Y1 - 1993

N2 - Herpesvirus saimiri (HVS) was used to infect and transform human CD8+ cytotoxic T lymphocytes (CTL), and the phenotypic and functional consequences of HVS infection of CD8+ T lymphocytes were investigated. HVS- transformed CTL no longer require antigen restimulation yet maintain their phenotype and HLA-restricted cytolytic function and specificity. The ability of HVS to transform CTL may have an important role in the functional analysis of human antigen-specific CTL.

AB - Herpesvirus saimiri (HVS) was used to infect and transform human CD8+ cytotoxic T lymphocytes (CTL), and the phenotypic and functional consequences of HVS infection of CD8+ T lymphocytes were investigated. HVS- transformed CTL no longer require antigen restimulation yet maintain their phenotype and HLA-restricted cytolytic function and specificity. The ability of HVS to transform CTL may have an important role in the functional analysis of human antigen-specific CTL.

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C2 - 8396687

AN - SCOPUS:0027239551

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JO - Journal of Virology

JF - Journal of Virology

IS - 10

ER -

Phenotypic and functional consequences of herpesvirus saimiri infection of human CD8⁺ cytotoxic T lymphocytes

Abstract

ASJC Scopus subject areas

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