Phenotype of schizophrenia: A review and formulation

C. A. Tamminga, H. H. Holcomb

Research output: Contribution to journalReview articlepeer-review

201 Scopus citations


The discovery of the pathophysiology(ies) for schizophrenia is necessary to direct rational treatment directions for this brain disorder. Firm knowledge about this illness is limited to areas of phenomenology, clinical eiectrophysioiogy, and genetic risk; some aspects of dopamine pharmacology, cognitive symptoms, and risk genes are known. Basic questions remain about diagnostic heterogeneity, tissue neurochemistry, and in vivo brain function. It is an illness ripe for molecular characterization using a rational approach with a confirmatory strategy; drug discovery based on knowledge is the only way to advance fully effective treatments. This paper reviews the status of general knowledge in this area and proposes an approach to discovery, including identifying brain regions of dysfunction and subsequent localized, hypothesis-driven molecular screening.

Original languageEnglish (US)
Pages (from-to)27-39
Number of pages13
JournalMolecular psychiatry
Issue number1
StatePublished - Jan 2005


  • Brain imaging
  • Limbic cortex
  • Psychosis
  • Schizophrenia
  • Signs and symptoms

ASJC Scopus subject areas

  • Molecular Biology
  • Cellular and Molecular Neuroscience
  • Psychiatry and Mental health


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