TY - JOUR
T1 - Phase I/II studies of docetaxel (Taxotere) combined with estramustine in men with hormone-refractory prostate cancer
AU - Petrylak, D. P.
AU - Macarthur, R.
AU - O'Connor, J.
AU - Shelton, G.
AU - Weitzman, A.
AU - Judge, T.
AU - England-Owen, C.
AU - Zuech, N.
AU - Pfaff, C.
AU - Newhouse, J.
AU - Bagiella, E.
AU - Hetjan, D.
AU - Sawczuk, I.
AU - Benson, M.
AU - Olsson, C.
PY - 1999
Y1 - 1999
N2 - Evaluation of the combined regimen of estramustine and docetaxel (Taxotere; Rhone-Poulenc Rorer, Collegeville, PA) in men with hormone- refractory prostate cancer is in its early stages. While this combination is promising in terms of efficacy, adverse events associated with estramustine are a concern. Estramustine has been associated with side effects such as nausea, vomiting, edema, and serious vascular events. Reported here are the results of phase I and phase II trials in which 280 mg estramustine was given three times daily on days I to 5 in 21-day treatment cycles with docetaxel at varying doses. Data from patients evaluable thus far support the efficacy of this combination, both in chemotherapeutically naive patients and in those who have had prior therapy. A survival benefit from this combination appears achievable from these early studies. As significant antitumor activity can be achieved with docetaxel alone, future studies need to define the minimal dose of estramustine for this combination.
AB - Evaluation of the combined regimen of estramustine and docetaxel (Taxotere; Rhone-Poulenc Rorer, Collegeville, PA) in men with hormone- refractory prostate cancer is in its early stages. While this combination is promising in terms of efficacy, adverse events associated with estramustine are a concern. Estramustine has been associated with side effects such as nausea, vomiting, edema, and serious vascular events. Reported here are the results of phase I and phase II trials in which 280 mg estramustine was given three times daily on days I to 5 in 21-day treatment cycles with docetaxel at varying doses. Data from patients evaluable thus far support the efficacy of this combination, both in chemotherapeutically naive patients and in those who have had prior therapy. A survival benefit from this combination appears achievable from these early studies. As significant antitumor activity can be achieved with docetaxel alone, future studies need to define the minimal dose of estramustine for this combination.
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M3 - Review article
C2 - 10604266
AN - SCOPUS:0033406879
SN - 0093-7754
VL - 26
SP - 28
EP - 33
JO - Seminars in oncology
JF - Seminars in oncology
IS - 5 SUPPL. 17
ER -