Abstract
Pediatric major depressive disorder (MDD) is a prevalent, chronic, and serious illness that causes short-term and life-long impairment in multiple areas of development and functioning of children and adolescents. The prevalence rates of pediatric MDD are estimated at 2.8% for children and 5.6% for adolescents, based on a recent meta-analysis of 26 studies, with a lifetime prevalence rate of 25%. The response (significant reduction of depressive symptoms) rate to a first antidepressant in randomized-controlled trials (RCTs) of children and adolescents with MDD is about 50% to 60%. About 40% to 50% of adolescents who failed one antidepressant responded to a second antidepressant. As in adult MDD, MDD in children and adolescents has high relapse rates (return of symptoms within the same episode) and recurrence (new episode).
Original language | English (US) |
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Pages (from-to) | 192-202 |
Number of pages | 11 |
Journal | Psychiatric Annals |
Volume | 40 |
Issue number | 4 |
DOIs | |
State | Published - Apr 2010 |
ASJC Scopus subject areas
- Psychiatry and Mental health