Pharmacotherapy for biochemical recurrences after therapy for localised prostate cancer

Kris E. Gaston, David K. Ornstein

Research output: Contribution to journalReview articlepeer-review


Prostate-specific antigen (PSA) has revolutionised screening for and monitoring of prostate cancer (CaP) [1]. Currently, most men failing potentially curative CaP therapies develop biochemical evidence of recurrent disease (defined by detectable PSA levels) long before the onset of clinical symptoms [1]. Androgen deprivation therapy (ADT) remains the gold standard for the treatment of metastatic CaP. Conventional ADT is orchiectomy or luteinising hormone-releasing hormone agonists. ADT is most commonly associated with side effects such as erectile dysfunction, decreased libido, gynecomastia and osteoporosis. Intermittent ADT or oral anti-androgens may limit the side effects associated with ADT while retaining efficacy. Although widely studied, the optimal timing to begin ADT remains an important and unanswered question. Future advances in gene therapy and immunotherapy hold the greatest promise to provide effective treatments against recurrent CaP while minimising morbidity.

Original languageEnglish (US)
Pages (from-to)657-669
Number of pages13
JournalExpert Opinion on Pharmacotherapy
Issue number6
StatePublished - 2002
Externally publishedYes


  • Androgen deprivation
  • Biochemical recurrence
  • Prostate cancer

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)


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