Pharmacological inhibitors of MAPK pathways

Jessie M. English, Melanie H. Cobb

Research output: Contribution to journalReview articlepeer-review

392 Scopus citations


Mitogen-activated protein kinases [MAPKs, also called extracellular signal-regulated kinases (ERKs)] are constituents of numerous signal transduction pathways, and are activated by protein kinase cascades. Intense efforts are under way to develop and evaluate compounds that target components of MAPK pathways. In this article, the current status of inhibitors of MAPK pathways will be presented with a focus on the properties of small-molecule inhibitors of p38, MEK1 and MEK2 protein kinases. Several of these inhibitors are effective in animal models of disease and have advanced to clinical trials for the treatment of inflammatory diseases and cancer. The clinical utility of specifically targeting a subset of cellular signaling cascades and signaling cascades that regulate pleiotropic cellular processes are being evaluated. The results of these efforts have broad implications for the treatment of many diseases.

Original languageEnglish (US)
Pages (from-to)40-45
Number of pages6
JournalTrends in Pharmacological Sciences
Issue number1
StatePublished - Jan 1 2002

ASJC Scopus subject areas

  • Toxicology
  • Pharmacology


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