Abstract
Rabbits with experimentally induced pneumococcal meningitis were given single 25-mg/kg doses of apalcillin or cefpiramide. Mean percentages of the drug concentration in cerebrospinal fluid versus that in blood serum were 7.6% with apalcillin and 3.9% with cefpiramide. Bactericidal activity in cerebrospinal fluid resulted in mean reductions of from 4 to 5 log10 CFU/ml, and cerebrospinal fluid cultures became sterile for 4 of 6 animals treated with each drug.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 578-579 |
| Number of pages | 2 |
| Journal | Antimicrobial agents and chemotherapy |
| Volume | 26 |
| Issue number | 4 |
| DOIs | |
| State | Published - 1984 |
ASJC Scopus subject areas
- Pharmacology
- Pharmacology (medical)
- Infectious Diseases