PH-responsive theranostic polymer-caged nanobins: Enhanced cytotoxicity and T1 MRI contrast by Her2 targeting

Bong Jin Hong; Elden P. Swindell; Keith W. MacRenaris; Patrick L. Hankins; Anthony J. Chipre; Daniel J. Mastarone; Richard W. Ahn; Thomas J. Meade; Thomas V. O'Halloran; Sonbinh T. Nguyen

doi:10.1002/ppsc.201300158

PH-responsive theranostic polymer-caged nanobins: Enhanced cytotoxicity and T₁ MRI contrast by Her2 targeting

Bong Jin Hong, Elden P. Swindell, Keith W. MacRenaris, Patrick L. Hankins, Anthony J. Chipre, Daniel J. Mastarone, Richard W. Ahn, Thomas J. Meade, Thomas V. O'Halloran, Sonbinh T. Nguyen

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

A polymer-caged nanobin (PCN) theranostic platform with a doxorubicin (DXR)-loaded liposomal core and an acid-sensitive polymer shell that is functionalized with herceptin and Gd^III-based magnetic resonance imaging (MRI) contrast agents is reported. In vitro testing reveals an 120-fold improvement in cellular Gd^III uptake in comparison with clinically approved DOTA-Gd^III, leading to significant T₁ MRI contrast enhancement.

Original language	English (US)
Pages (from-to)	770-774
Number of pages	5
Journal	Particle and Particle Systems Characterization
Volume	30
Issue number	9
DOIs	https://doi.org/10.1002/ppsc.201300158
State	Published - Sep 2013
Externally published	Yes

Keywords

cancer targeting
drug delivery
magnetic resonance imaging
pH-responsive drug release
theranostics

ASJC Scopus subject areas

Chemistry(all)
Materials Science(all)
Condensed Matter Physics

Access to Document

10.1002/ppsc.201300158

Cite this

Hong, B. J., Swindell, E. P., MacRenaris, K. W., Hankins, P. L., Chipre, A. J., Mastarone, D. J., Ahn, R. W., Meade, T. J., O'Halloran, T. V., & Nguyen, S. T. (2013). PH-responsive theranostic polymer-caged nanobins: Enhanced cytotoxicity and T₁ MRI contrast by Her2 targeting. Particle and Particle Systems Characterization, 30(9), 770-774. https://doi.org/10.1002/ppsc.201300158

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abstract = "A polymer-caged nanobin (PCN) theranostic platform with a doxorubicin (DXR)-loaded liposomal core and an acid-sensitive polymer shell that is functionalized with herceptin and GdIII-based magnetic resonance imaging (MRI) contrast agents is reported. In vitro testing reveals an 120-fold improvement in cellular GdIII uptake in comparison with clinically approved DOTA-GdIII, leading to significant T1 MRI contrast enhancement.",

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