Pet-fdg test-re test reliability during a visual discrimination task in schizophrenia

H. H. Holcomb, N. G. Cascella, D. R. Medoff, E. A. Gastineau, H. Loats, G. K. Thaker, R. R. Conley, R. F. Dannals, H. N. Wagner, C. A. Tamminga

Research output: Contribution to journalArticlepeer-review

20 Scopus citations


Objective: Reliability of assessment is important in any kind of neuropsychiatric study, but is particularly pivotal in schizophrenia research where symptom instability is common. Materials and Methods: Two fluorodeoxyglucose PET scans, 1 week apart, were carried out in schizophrenic patients while they were performing a simple visual discrimination task. Subject and scan conditions were held constant. Regional metabolic rates of glucose utilization were calculated as absolute and scaled; they were compared using correlational statistics. Results: Average differences between scans were 5-9% for the parietal and occipital cortices, but 1-3% for other cortical areas, differences comparable with reported variances in normal controls. Conclusion: These results suggest that test-retest variance in metabolic im-aging in schizophrenia is relatively low and that task performance increases metabolic stability in brain areas unrelated to task performance.

Original languageEnglish (US)
Pages (from-to)704-709
Number of pages6
JournalJournal of computer assisted tomography
Issue number5
StatePublished - 1993


  • Emission computed tomography
  • Fluorodeoxyglucose (FDG)
  • Glucose
  • Metabolism
  • Schizophrenia

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging


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