Persistent Hypertransaminasemia as the Presenting Finding of Childhood Muscle Disease

J. Rutledge, J. Andersen, C. W. Fink, J. Cook, A. Strickland

Research output: Contribution to journalArticlepeer-review

28 Scopus citations


Four children with isolated, persistent elevations of serum transaminases were investigated for hepatic disease and followed for 4 to 24 months before serum creatine kinase determinations were obtained and found to be markedly elevated. Evidence of muscle disease was obtained by close questioning, retrospectively, and mild abnormalities were found on physical examination. Review of laboratory tests in our center for 6 months revealed 30 additional cases of anicteric hypertransaminasemia (20% of those with elevated enzymes), only two of which were unexplained by the admitting diagnosis. Serum transaminase values are elevated in a variety of diseases of different organ systems. Creatine kinase determinations may provide the clue to the diagnosis of occult muscle disease in some children with unexplained anicteric hypertransaminasemia.

Original languageEnglish (US)
Pages (from-to)500-503
Number of pages4
JournalClinical Pediatrics
Issue number9
StatePublished - Sep 1985

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health


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