Peritoneal Metastases in Colorectal Cancer: Biology and Barriers

Lai Xue, Neil H. Hyman, Kiran K. Turaga, Oliver S. Eng

Research output: Contribution to journalReview articlepeer-review

12 Scopus citations


Background: Advances in the molecular biology of tumor metastasis have paralleled the evolution in the management of metastatic disease from colorectal cancer. In this review, we summarize the current understanding of the mechanism of colorectal cancer metastases, in particular that of peritoneal metastases, as well as clinical data on the treatment of this disease. Methods: A review of relevant English literature using MEDLINE/PubMed on the biology of colorectal cancer metastases, determinants of oligometastasis, and use of cytoreductive surgery and hyperthermic intraperitoneal chemotherapy in the treatment of metastatic colorectal cancer is presented. Results: Recognition of oligometastasis in the evolution of colorectal peritoneal metastases provides the theoretical framework for which cytoreductive surgery with or without hyperthermic intraperitoneal chemotherapy is considered. Clearly, a subset of patients benefit from peritoneal metastasectomy. Conclusion: Advances in cancer biology and clinical imaging promise to expand the role of cytoreductive surgery with or without intraperitoneal chemotherapy in the management of peritoneal metastases from colorectal cancer.

Original languageEnglish (US)
Pages (from-to)720-727
Number of pages8
JournalJournal of Gastrointestinal Surgery
Issue number3
StatePublished - Mar 1 2020
Externally publishedYes


  • Biology
  • Colorectal cancer
  • Peritoneal metastases
  • Review

ASJC Scopus subject areas

  • Surgery
  • Gastroenterology


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