Peripheral intraosseous carcinoma arising from a recurrent odontogenic keratocyst

Isherpreet Shergill, Thomas Schlieve, Fayette Williams, Roderick Kim, Daniel Hammer

Research output: Contribution to journalArticlepeer-review


Primary intraosseous carcinoma (PIOC) is a distinct clinical and genomic pathology that should be considered when treating aggressive odontogenic cysts refractory to standard treatments. Odontogenic cysts have a very low chance of malignant transformation, with most studies citing an incidence of <0.05%. The pathogenesis of PIOC is multifactorial, with chronic inflammation-induced carcinogenesis being the most cited theory. Early detection is imperative to enhance the patient’s prognosis, with the 5-year overall survival rate of PIOC being 38%. This paper presents a case of PIOC and reviews data on its epidemiology, diagnosis, presentation, and treatment.

Original languageEnglish (US)
Pages (from-to)91-92
Number of pages2
JournalBaylor University Medical Center Proceedings
Issue number1
StatePublished - 2023


  • Odontogenic cysts
  • odontogenic keratocyst
  • PIOC
  • primary intraosseous carcinoma

ASJC Scopus subject areas

  • Medicine(all)


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