Perfluorocarbon liquids in ophthalmology

Steven G. Kramer, David Hwang, Gholam A. Peyman, Joel A. Schulman, Brian Sullivan

Research output: Contribution to journalArticlepeer-review

128 Scopus citations


Perfluorocarbon liquids have been used to facilitate surgery in a wide variety of conditions, including proliferative vitreoretinopathy, giant retinal tears, drainge of suprachoroidal hemorrhages, diabetic traction, retinal detachments with a rhegmatogenous component, dislocated crystalline or intraocular lenses, and retinal detachment associated with choroidal coloboma. The clarity of perfluorocarbon liquids, with a refractive index close to that of water, allows the use of a conventional contact lens for vitreous surgery while the low viscosity facilitates tissue manipulation, injection, and removal. All perfluorocarbon liquids when used as tamponading agents can compress and disorganize the retina. This "toxicity" is a physical effect rather than chemical toxicity and depends upon the amount of perfluorocarbon liquid injected. Perfluorocarbon liquids are not tolerated in the anterior chamber, causing corneal edema within 2-3 days at the site of contact.

Original languageEnglish (US)
Pages (from-to)375-395
Number of pages21
JournalSurvey of Ophthalmology
Issue number5
StatePublished - 1995


  • perfluorocarbon liquids
  • retinal detachment
  • vitreous substitutes

ASJC Scopus subject areas

  • Ophthalmology


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