TY - JOUR
T1 - Perceived Stress is Associated with Alzheimer's Disease Cerebrospinal Fluid Biomarkers in African Americans with Mild Cognitive Impairment
AU - Trammell, Antoine R.
AU - McDaniel, Darius J.
AU - Obideen, Malik
AU - Okafor, Maureen
AU - Thomas, Tiffany L.
AU - Goldstein, Felicia C.
AU - Shaw, Leslie M.
AU - Hajjar, Ihab M.
N1 - Funding Information:
This research was funded by the National Institutes of Health/National Institute on Aging (Grant No. NIA: RF1AG051633-01 and Grant No. R01-AG042127-06). Additional funding was received from a Diversity Supplement from the National Institute on Aging (Grant No. NIA: RF1AG051633-01S1) and the Alzheimer’s Association (AARGD-NTF-20-644587).
Funding Information:
This research was funded by the National Institutes of Health/National Institute on Aging (Grant No. NIA: RF1AG051633-01 and Grant No. R01-AG042127-06). Additional funding was received from a Diversity Supplement from the National Institute on Aging (Grant No. NIA: RF1AG051633-01S1) and the Alzheimer s Association (AARGD-NTF-20-644587).
Publisher Copyright:
© 2020 - IOS Press and the authors. All rights reserved.
PY - 2020
Y1 - 2020
N2 - Background: African Americans (AA) have a higher Alzheimer's disease (AD) prevalence and report more perceived stress than White Americans. The biological basis of the stress-AD link is unclear. This study investigates the connection between stress and AD biomarkers in a biracial cohort. Objective: Establish biomarker evidence for the observed association between stress and AD, especially in AA. Methods: A cross-sectional study (n = 364, 41.8% AA) administering cognitive tests and the perceived stress scale (PSS) questionnaire. A subset (n = 309) provided cerebrospinal fluid for measurement of Aβ42, Tau, Ptau, Tau/Aβ42 (TAR), and Ptau/Aβ42 (PTAR). Multivariate linear regression, including factors that confound racial differences in AD, was performed. Results: Higher PSS scores were associated with higher Ptau (β= 0.43, p = 0.01) and PTAR (β= 0.005, p = 0.03) in AA with impaired cognition (mild cognitive impairment). Conclusion: Higher PSS scores were associated with Tau-related AD biomarker indices in AA/MCI, suggesting a potential biological connection for stress with AD and its racial disparity.
AB - Background: African Americans (AA) have a higher Alzheimer's disease (AD) prevalence and report more perceived stress than White Americans. The biological basis of the stress-AD link is unclear. This study investigates the connection between stress and AD biomarkers in a biracial cohort. Objective: Establish biomarker evidence for the observed association between stress and AD, especially in AA. Methods: A cross-sectional study (n = 364, 41.8% AA) administering cognitive tests and the perceived stress scale (PSS) questionnaire. A subset (n = 309) provided cerebrospinal fluid for measurement of Aβ42, Tau, Ptau, Tau/Aβ42 (TAR), and Ptau/Aβ42 (PTAR). Multivariate linear regression, including factors that confound racial differences in AD, was performed. Results: Higher PSS scores were associated with higher Ptau (β= 0.43, p = 0.01) and PTAR (β= 0.005, p = 0.03) in AA with impaired cognition (mild cognitive impairment). Conclusion: Higher PSS scores were associated with Tau-related AD biomarker indices in AA/MCI, suggesting a potential biological connection for stress with AD and its racial disparity.
KW - African Americans
KW - Alzheimer's disease
KW - amyloid-β peptides
KW - cognitive function
KW - mild cognitive impairment
KW - neurocognitive tests
KW - psychological stress
KW - tauopathy
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U2 - 10.3233/JAD-200089
DO - 10.3233/JAD-200089
M3 - Article
C2 - 32741810
AN - SCOPUS:85091470093
SN - 1387-2877
VL - 77
SP - 843
EP - 853
JO - Journal of Alzheimer's Disease
JF - Journal of Alzheimer's Disease
IS - 2
ER -