TY - JOUR
T1 - Pentagalloyl Glucose and Its Functional Role in Vascular Health
T2 - Biomechanics and Drug-Delivery Characteristics
AU - Patnaik, Sourav S.
AU - Simionescu, Dan T.
AU - Goergen, Craig J.
AU - Hoyt, Kenneth
AU - Sirsi, Shashank
AU - Finol, Ender A.
N1 - Funding Information:
The authors have no conflicts of interest to disclose and would like to acknowledge research funding from American Heart Association Award #16CSA28480006.
Publisher Copyright:
© 2018, Biomedical Engineering Society.
PY - 2019/1/15
Y1 - 2019/1/15
N2 - Pentagalloyl glucose (PGG) is an elastin-stabilizing polyphenolic compound that has significant biomedical benefits, such as being a free radical sink, an anti-inflammatory agent, anti-diabetic agent, enzymatic resistant properties, etc. This review article focuses on the important benefits of PGG on vascular health, including its role in tissue mechanics, the different modes of pharmacological administration (e.g., oral, intravenous and endovascular route, intraperitoneal route, subcutaneous route, and nanoparticle based delivery and microbubble-based delivery), and its potential therapeutic role in vascular diseases such as abdominal aortic aneurysms (AAA). In particular, the use of PGG for AAA suppression and prevention has been demonstrated to be effective only in the calcium chloride rat AAA model. Therefore, in this critical review we address the challenges that lie ahead for the clinical translation of PGG as an AAA growth suppressor.
AB - Pentagalloyl glucose (PGG) is an elastin-stabilizing polyphenolic compound that has significant biomedical benefits, such as being a free radical sink, an anti-inflammatory agent, anti-diabetic agent, enzymatic resistant properties, etc. This review article focuses on the important benefits of PGG on vascular health, including its role in tissue mechanics, the different modes of pharmacological administration (e.g., oral, intravenous and endovascular route, intraperitoneal route, subcutaneous route, and nanoparticle based delivery and microbubble-based delivery), and its potential therapeutic role in vascular diseases such as abdominal aortic aneurysms (AAA). In particular, the use of PGG for AAA suppression and prevention has been demonstrated to be effective only in the calcium chloride rat AAA model. Therefore, in this critical review we address the challenges that lie ahead for the clinical translation of PGG as an AAA growth suppressor.
KW - Abdominal aortic aneurysms
KW - Collagen
KW - Drug delivery
KW - Elastin
KW - Pentagalloyl glucose
UR - http://www.scopus.com/inward/record.url?scp=85054843515&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85054843515&partnerID=8YFLogxK
U2 - 10.1007/s10439-018-02145-5
DO - 10.1007/s10439-018-02145-5
M3 - Review article
C2 - 30298373
AN - SCOPUS:85054843515
SN - 0090-6964
VL - 47
SP - 39
EP - 59
JO - Annals of biomedical engineering
JF - Annals of biomedical engineering
IS - 1
ER -